Evidence map›Paper›PMID 26116903›Full record

ReviewExperimental eye research2015

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Kimberly A Fernandes, Jeffrey M Harder, Pete A Williams, Rebecca L Rausch, Amy E Kiernan, K Saidas Nair, Michael G Anderson, Simon W M John, Gareth R Howell, Richard T Libby

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Characterization of the Retinal Circulation of the Mouse.Investigative ophthalmology & visual science · 2024
    Article
  7. DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH.Investigative ophthalmology & visual science · 2024
    Article
  8. Article
  9. Exploring the Genetic Landscape of Childhood Glaucoma.Children (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Glaucoma Animal Models beyond Chronic IOP Increase.International journal of molecular sciences · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Differential susceptibility of retinal ganglion cell subtypes against neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kimberly A FernandesFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA.
Jeffrey M HarderThe Jackson Laboratory, Bar Harbor, ME, USA.
Pete A WilliamsThe Jackson Laboratory, Bar Harbor, ME, USA.
Rebecca L RauschFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA; Interdepartmental Graduate Program in Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Amy E KiernanFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
K Saidas NairDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Michael G AndersonDepartment of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA, USA; Center for the Prevention and Treatment of Visual Loss, Iowa City Veterans Affairs (VA) Health Care System, Iowa City, IA, USA.
Simon W M JohnThe Jackson Laboratory, Bar Harbor, ME, USA; The Howard Hughes Medical Institute, Bar Harbor, ME, USA.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME, USA.
Richard T LibbyFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: richard_libby@urmc.rochester.edu.

Funding

Factors Determining Intraocular Pressure and Glaucoma SusceptibilityR01EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 2002 to 2018
$12.4M
VISUAL SCIENCET32EY007125 · NEI · UNIVERSITY OF ROCHESTER · PI Krystel R Huxlin, Duje Tadin · 1990 to 2026
$7.1M
Cell Death Pathways in Glaucomatous NeurodegenerationR01EY018606 · NEI · UNIVERSITY OF ROCHESTER · PI JOHN, SIMON W, LIBBY, RICHARD T · 2008 to 2023
$5.8M
Genetic dissection of pigment dispersing iris diseaseR01EY017673 · NEI · UNIVERSITY OF IOWA · PI ANDERSON, MICHAEL G · 2008 to 2017
$3.1M
Investigating Cell Specific Roles of the Complement Cascade in GlaucomaR01EY021525 · NEI · JACKSON LABORATORY · PI HOWELL, GARETH R · 2012 to 2016
$2.5M
Determining Molecular and Cellular Mechanisms of GlaucomaR01EY022891 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAIR, KAYARAT SAIDAS · 2013 to 2017
$2.0M
FACTORS DETERMINING INTRAOCULAR PRESSURER29EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 1997 to 2001
$227k
NEI NIH HHS EY011721NEI NIH HHS EY018606NEI NIH HHS EY021525NEI NIH HHS EY022891NEI NIH HHS R01 EY011721NEI NIH HHS R01 EY017673NEI NIH HHS R01 EY018606NEI NIH HHS R01 EY021525NEI NIH HHS R01 EY022891NEI NIH HHS R29 EY011721NEI NIH HHS T32 EY007125
6 · The paper itself

Abstract

While all forms of glaucoma are characterized by a specific pattern of retinal ganglion cell death, they are clinically divided into several distinct subclasses, including normal tension glaucoma, primary open angle glaucoma, congenital glaucoma, and secondary glaucoma. For each type of glaucoma there are likely numerous molecular pathways that control susceptibility to the disease. Given this complexity, a single animal model will never precisely model all aspects of all the different types of human glaucoma. Therefore, multiple animal models have been utilized to study glaucoma but more are needed. Because of the powerful genetic tools available to use in the laboratory mouse, it has proven to be a highly useful mammalian system for studying the pathophysiology of human disease. The similarity between human and mouse eyes coupled with the ability to use a combination of advanced cell biological and genetic tools in mice have led to a large increase in the number of studies using mice to model specific glaucoma phenotypes. Over the last decade, numerous new mouse models and genetic tools have emerged, providing important insight into the cell biology and genetics of glaucoma. In this review, we describe available mouse genetic models that can be used to study glaucoma-relevant disease/pathobiology. Furthermore, we discuss how these models have been used to gain insights into ocular hypertension (a major risk factor for glaucoma) and glaucomatous retinal ganglion cell death. Finally, the potential for developing new mouse models and using advanced genetic tools and resources for studying glaucoma are discussed.

Indexed as

Intraocular PressureAnimalsDisease Models, AnimalGlaucomaHumansMiceRetinal Ganglion CellsAxonal degenerationDBA/2JGenomicsIOPMouse geneticsNeurodegenerationNeuroinflammationTrabecular meshwork

Identifiers

PMID26116903
PMCPMC4628898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.