ReviewAesthetic surgery journal2015
Lymphomas Associated with Breast Implants: A Review of the Literature.
Review in Aesthetic surgery journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The Risk of Breast Implant-Associated Anaplastic Large Cell Lymphoma; A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2024Pooled it
- Bilateral breast implant-associated anaplastic large cell lymphoma presenting as late peri-implant effusion: a case report.Journal of surgical case reports · 2026Article
- Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery.Nature communications · 2021Article
- Biopsy Results Are Not Sufficient to Exclude Breast Implant-associated Anaplastic Large Cell Lymphoma: A Case Mistaken for Disseminated Silicosis.Plastic and reconstructive surgery. Global open · 2020Article
- Description of Two Cases of Anaplastic Large Cell Lymphoma Associated with a Breast Implant.Case reports in radiology · 2019Article
- A Rare Case of Breast Implant-Associated Diffuse Large B-Cell Lymphoma.Case reports in oncological medicine · 2019Article
- The A, B and C's of Silicone Breast Implants: Anaplastic Large Cell Lymphoma, Biofilm and Capsular Contracture.Materials (Basel, Switzerland) · 2018Review
- Spontaneous Regression and Resolution of Breast Implant-Associated Anaplastic Large Cell Lymphoma: Implications for Research, Diagnosis and Clinical Management.Aesthetic plastic surgery · 2018Review
- Silicone Granuloma Associated with Pectoral Muscle Involvement after Ruptured Breast Implant: a Novel case report.European journal of breast health · 2018Article
- Breast reconstruction with anatomical implants: A review of indications and techniques based on current literature.Annals of medicine and surgery (2012) · 2017Review
- Primary Breast Lymphoma in the United States: 1975-2013.Journal of the National Cancer Institute · 2017Article
- The waterfall effect in breast augmentation.Gland surgery · 2017Review
- Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report and Literature Review.Cureus · 2016Article
- Commentary on: Lymphomas Associated With Breast Implants: A Review of the Literature.Aesthetic surgery journal · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently there have been concerns raised about anaplastic large cell lymphoma (ALCL) associated with breast implants.
objectivesThe main aim of this article was to review and analyze the published literature specifically for hematopoietic malignancies associated with breast implants and postulate a hypothesis for their etiology and pathogenesis.
methodsThe PubMed database was searched using key words "lymphoma" and "breast implants" for published papers and abstracts on implant-associated hematopoietic malignancies.
resultsThe authors found 83 published cases reported of lymphomas associated with breast implants in the medical literature. The reported cases involved various subtypes of lymphomas and the majority were ALCL, of which 66 were confirmed as ALK negative; however there was no association with any particular type of implant. The more aggressive cases and reported low death rate appeared to be related to the presence of breast masses at the time of presentation rather than effusion. The remaining reports were occasional case reports of T-cell lymphoma, follicular lymphoma, marginal zone B-cell lymphoma, primary effusion lymphoma and lymphoplasmacytic lymphoma.
conclusionsConsidering the many thousands of women that have breast implants every year; the compiled data show that there is a very small risk of developing lymphoma. Increased awareness of association between implants and ALCL is needed globally and prospective patients considering breast implants should be fully informed of the risk. As the behavior of ALCL in these cases was indolent as compared with other primary breast lymphomas, it could suggest an abnormal reactive process. LEVEL OF EVIDENCE: 3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.