ArticleApplied and environmental microbiology2015
Clostridium botulinum Group II Isolate Phylogenomic Profiling Using Whole-Genome Sequence Data.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genomic Diversity, Competition, and Toxin Production by Group I and IIMicroorganisms · 2022Article
- Selection and Development of Nontoxic NonproteolyticFoods (Basel, Switzerland) · 2022Article
- Extensive Genome Exploration ofMicroorganisms · 2021Article
- Pan-Genomic Analysis ofToxins · 2020Article
- The orphan germinant receptor protein GerXAO (but not GerX3b) is essential for L-alanine induced germination in Clostridium botulinum Group II.Scientific reports · 2018Article
- Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance.Frontiers in bioengineering and biotechnology · 2018Review
- Canonical germinant receptor is dispensable for spore germination in Clostridium botulinum group II strain NCTC 11219.Scientific reports · 2017Article
- Differentiating Botulinum Neurotoxin-Producing Clostridia with a Simple, Multiplex PCR Assay.Applied and environmental microbiology · 2017Article
- A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis.Frontiers in microbiology · 2017Article
- The Importance of Bacterial Culture to Food Microbiology in the Age of Genomics.Frontiers in microbiology · 2017Review
- Navigating Microbiological Food Safety in the Era of Whole-Genome Sequencing.Clinical microbiology reviews · 2016Review
- Impact ofCurrent opinion in food science · 2016Review
- Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes.Genome biology and evolution · 2016Article
- Comparative genomic analyses reveal broad diversity in botulinum-toxin-producing Clostridia.BMC genomics · 2016Article
- Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts.Genome biology and evolution · 2016Article
- New Insights into the Genetic Diversity of Clostridium botulinum Group III through Extensive Genome Exploration.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium botulinum group II isolates (n = 163) from different geographic regions, outbreaks, and neurotoxin types and subtypes were characterized in silico using whole-genome sequence data. Two clusters representing a variety of botulinum neurotoxin (BoNT) types and subtypes were identified by multilocus sequence typing (MLST) and core single nucleotide polymorphism (SNP) analysis. While one cluster included BoNT/B4/F6/E9 and nontoxigenic members, the other comprised a wide variety of different BoNT/E subtype isolates and a nontoxigenic strain. In silico MLST and core SNP methods were consistent in terms of clade-level isolate classification; however, core SNP analysis showed higher resolution capability. Furthermore, core SNP analysis correctly distinguished isolates by outbreak and location. This study illustrated the utility of next-generation sequence-based typing approaches for isolate characterization and source attribution and identified discrete SNP loci and MLST alleles for isolate comparison.
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