ArticleApplied and environmental microbiology2015
A Caleosin-Like Protein with Peroxygenase Activity Mediates Aspergillus flavus Development, Aflatoxin Accumulation, and Seed Infection.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Lipid droplet proteome plasticity in plant evolution, growth and development, and response to stress.Journal of experimental botany · 2026Review
- Plant Lipid Droplets and Derived Lipidic Nano-Assemblies: Structure, Biogenesis and Pharmaceutical Applications.Plant biotechnology journal · 2026Review
- A new 13-lipoxygenase from Taxus media callus is functionally linked to paclitaxel biosynthesis.Scientific reports · 2025Article
- Origin, evolution and diversification of plant caleosins.BMC plant biology · 2025Article
- Plant oxylipins: adaptation to environmental stresses and impact on mycotoxin contamination.Frontiers in plant science · 2025Review
- Genomic Analysis of the Caleosin Family in Theaceae Reveals Lineagespecific Evolutionary Patterns.Current protein & peptide science · 2025Article
- Unveiling the Secrets of Calcium-Dependent Proteins in Plant Growth-Promoting Rhizobacteria: An Abundance of Discoveries Awaits.Plants (Basel, Switzerland) · 2023Review
- Caleosin/peroxygenases: multifunctional proteins in plants.Annals of botany · 2023Review
- Characterization of lipid droplets from a Taxus media cell suspension and their potential involvement in trafficking and secretion of paclitaxel.Plant cell reports · 2022Article
- Insights into the control of taxane metabolism: Molecular, cellular, and metabolic changes induced by elicitation inFrontiers in plant science · 2022Article
- Involvement of hepatic lipid droplets and their associated proteins in the detoxification of aflatoxin BToxicology reports · 2020Article
- Comprehensive Transcriptome and Proteome Analyses Reveal the Modulation of Aflatoxin Production byFrontiers in microbiology · 2020Article
- Exposure ofFrontiers in microbiology · 2019Article
- Evolutionary, structural and functional analysis of the caleosin/peroxygenase gene family in the Fungi.BMC genomics · 2018Article
- Identification of a dioxin-responsive oxylipin signature in roots of date palm: involvement of a 9-hydroperoxide fatty acid reductase, caleosin/peroxygenase PdPXG2.Scientific reports · 2018Article
- Evolutionary and genomic analysis of the caleosin/peroxygenase (CLO/PXG) gene/protein families in the Viridiplantae.PloS one · 2018Article
- Horizontal Gene Transfer From Bacteria and Plants to the Arbuscular Mycorrhizal FungusFrontiers in plant science · 2018Article
- Large-Scale Comparative Analysis of Eugenol-Induced/Repressed Genes Expression inFrontiers in microbiology · 2018Article
- The Peroxygenase Activity of theFrontiers in microbiology · 2018Article
- Characterization of the Far Transcription Factor Family in Aspergillus flavus.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caleosins are a small family of calcium-binding proteins endowed with peroxygenase activity in plants. Caleosin-like genes are present in fungi; however, their functions have not been reported yet. In this work, we identify a plant caleosin-like protein in Aspergillus flavus that is highly expressed during the early stages of spore germination. A recombinant purified 32-kDa caleosin-like protein supported peroxygenase activities, including co-oxidation reactions and reduction of polyunsaturated fatty acid hydroperoxides. Deletion of the caleosin gene prevented fungal development. Alternatively, silencing of the gene led to the increased accumulation of endogenous polyunsaturated fatty acid hydroperoxides and antioxidant activities but to a reduction of fungal growth and conidium formation. Two key genes of the aflatoxin biosynthesis pathway, aflR and aflD, were downregulated in the strains in which A. flavus PXG (AfPXG) was silenced, leading to reduced aflatoxin B1 production in vitro. Application of caleosin/peroxygenase-derived oxylipins restored the wild-type phenotype in the strains in which AfPXG was silenced. PXG-deficient A. flavus strains were severely compromised in their capacity to infect maize seeds and to produce aflatoxin. Our results uncover a new branch of the fungal oxylipin pathway and may lead to the development of novel targets for controlling fungal disease.
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