ArticleDevelopment (Cambridge, England)2015
Inhibitory neuron migration and IPL formation in the developing zebrafish retina.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Determining the Migration Behavior of Retinal Progenitor Cells in the Embryonic Eye Field ofbioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination.Cell reports · 2026Article
- Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories.Cell reports · 2024Article
- CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids.Stem cell research & therapy · 2023Article
- Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territory.bioRxiv : the preprint server for biology · 2023Article
- Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Deterministic and probabilistic fate decisions co-exist in a single retinal lineage.The EMBO journal · 2023Article
- Retinal self-organization: a model of retinal ganglion cells and starburst amacrine cells mosaic formation.Open biology · 2023Article
- Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina.eLife · 2022Article
- Article
- Repeated nuclear translocations underlie photoreceptor positioning and lamination of the outer nuclear layer in the mammalian retina.Cell reports · 2021Article
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Article
- Making sense of neural development by comparing wiring strategies for seeing and hearing.Science (New York, N.Y.) · 2021Review
- Dendrite morphogenesis from birth to adulthood.Current opinion in neurobiology · 2018Review
- P2YMolecular neurobiology · 2018Article
- Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.eLife · 2018Article
- RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.Development (Cambridge, England) · 2018Article
- Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination.Development (Cambridge, England) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
The mature vertebrate retina is a highly ordered neuronal network of cell bodies and synaptic neuropils arranged in distinct layers. Little, however, is known about the emergence of this spatial arrangement. Here, we investigate how the three main types of retinal inhibitory neuron (RIN)--horizontal cells (HCs), inner nuclear layer amacrine cells (iACs) and displaced amacrine cells (dACs)--reach their specific laminar positions during development. Using in vivo time-lapse imaging of zebrafish retinas, we show that RINs undergo distinct phases of migration. The first phase, common to all RINs, is bipolar migration directed towards the apicobasal centre of the retina. All RINs then transition to a less directionally persistent multipolar phase of migration. Finally, HCs, iACs and dACs each undergo cell type-specific migration. In contrast to current hypotheses, we find that most dACs send processes into the forming inner plexiform layer (IPL) before migrating through it and inverting their polarity. By imaging and quantifying the dynamics of HCs, iACs and dACs from birth to final position, this study thus provides evidence for distinct and new migration patterns during retinal lamination and insights into the initiation of IPL formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.