ArticleArchives of biochemistry and biophysics2015
Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice.
Article in Archives of biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- The Role of Uridine in Health and Disease.Journal of inflammation research · 2025Review
- Targeting the gut microbiota and lipid metabolism: potential mechanisms of natural products for the treatment of non-alcoholic fatty liver disease.Frontiers in pharmacology · 2025Review
- Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases.Frontiers in physiology · 2024Review
- Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis.Genes & diseases · 2023Review
- Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice.Cell death & disease · 2022Article
- Article
- An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease.BioMed research international · 2020Review
- Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis.BioMed research international · 2020Review
- Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.Journal of experimental & clinical cancer research : CR · 2019Article
- The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms.Endocrinology · 2018Article
- Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice.The Journal of biological chemistry · 2018Article
- ΔJournal of lipid research · 2018Article
- Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet.Journal of lipid research · 2017Article
- Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds.Oncotarget · 2017Article
- Evolution of the duplicated intracellular lipid-binding protein genes of teleost fishes.Molecular genetics and genomics : MGG · 2017Review
- Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice.Lipids · 2017Article
- FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.Biochemistry · 2016Article
- FABP-1 gene ablation impacts brain endocannabinoid system in male mice.Journal of neurochemistry · 2016Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although roles for both sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) and liver fatty acid binding protein (L-FABP) have been proposed in hepatic lipid accumulation, individually ablating these genes has been complicated by concomitant alterations in the other gene product(s). For example, ablating SCP2/SCP-x induces upregulation of L-FABP in female mice. Therefore, the impact of ablating SCP-2/SCP-x (DKO) or L-FABP (LKO) individually or both together (TKO) was examined in female mice. Loss of SCP-2/SCP-x (DKO, TKO) more so than loss of L-FABP alone (LKO) increased hepatic total lipid and total cholesterol content, especially cholesteryl ester. Hepatic accumulation of nonesterified long chain fatty acids (LCFA) and phospholipids occurred only in DKO and TKO mice. Loss of SCP-2/SCP-x (DKO, TKO) increased serum total lipid primarily by increasing triglycerides. Altered hepatic level of proteins involved in cholesterol uptake, efflux, and/or secretion was observed, but did not compensate for the loss of L-FABP, SCP-2/SCP-x or both. However, synergistic responses were not seen with the combinatorial knock out animals-suggesting that inhibiting SCP-2/SCP-x is more correlative with hepatic dysfunction than L-FABP. The DKO- and TKO-induced hepatic accumulation of cholesterol and long chain fatty acids shared significant phenotypic similarities with non-alcoholic fatty liver disease (NAFLD).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.