ReviewJournal of microbiology (Seoul, Korea)2015
Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration?
Review in Journal of microbiology (Seoul, Korea), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 139 citations in OpenAlex.
- Integrative multi-omics analysis uncovers tumor-immune-gut axis influencing immunotherapy outcomes in ovarian cancer.Nature communications · 2024Trial
- Is Fluorescence Valid to Monitor Removal of Protein Bound Uremic Solutes in Dialysis?PloS one · 2016Trial
- The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive-Like Behavior in Mice.Brain and behavior · 2026Article
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Microbiota-derived indole differentially shapes Entamoeba histolytica physiology and promotes host-compatible colonization.PLoS neglected tropical diseases · 2026Article
- A Methyl-Accepting Chemotaxis Protein MCP-5685 Associated with Indole Synthesis in Pantoea ananatis YJ76 Influences its Plant Growth-Promoting Potential and Adaptability to Stress Conditions.Current microbiology · 2025Article
- Modulation of virulence and metabolic profiles inFrontiers in cellular and infection microbiology · 2025Article
- Exogenous indole modulates several CpxRA-mediated virulence-related parameters ofMarine life science & technology · 2024Article
- Auxin-mediated regulation of susceptibility to toxic metabolites, c-di-GMP levels, and phage infection in the rhizobacteriummSystems · 2024Article
- Unraveling the Dynamics of Host-Microbiota Indole Metabolism: An Investigation of Indole, Indolin-2-one, Isatin, and 3-Hydroxyindolin-2-one.Molecules (Basel, Switzerland) · 2024Article
- Characterization of the IAA-Producing and -DegradingInternational journal of molecular sciences · 2023Article
- Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly.Microbiome · 2023Article
- Environmental conditions define the energetics of bacterial dormancy and its antibiotic susceptibility.Biophysical journal · 2023Article
- A response regulator controlsPNAS nexus · 2023Article
- The Synthesis and Biological Evaluation of 2-(1Molecules (Basel, Switzerland) · 2023Article
- Proteomic analysis reveals the adaptation of Vibrio splendidus to an iron deprivation condition.Applied microbiology and biotechnology · 2023Article
- Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response.BMC biology · 2023Article
- Pseudomonas aeruginosa Resists Phage Infection via Eavesdropping on Indole Signaling.Microbiology spectrum · 2023Article
- Stable isotope-assisted metabolite profiling reveals new insights into L-tryptophan chemotrophic metabolism of Rubrivivax benzoatilyticus.World journal of microbiology & biotechnology · 2023Article
- The determination of the biological function of bacterial pink pigment andFrontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indole is an organic compound that is widespread in microbial communities inhabiting diverse habitats, like the soil environment and human intestines. Measurement of indole production is a traditional method for the identification of microbial species. Escherichia coli can produce millimolar concentrations of indole in the stationary growth phase under nutrient-rich conditions. Indole has received considerable attention because of its remarkable effects on various biological functions of the microbial communities, for example, biofilm formation, motility, virulence, plasmid stability, and antibiotic resistance. Indole may function as an intercellular signaling molecule, like a quorum-sensing signal. Nevertheless, a receptor system for indole and the function of this compound in coordinated behavior of a microbial population (which are requirements for a true signaling molecule) have not yet been confirmed. Recent findings suggest that a long-known quorum-sensing regulator, E. coli's SdiA, cannot recognize indole and that this compound may simply cause membrane disruption and energy reduction, which can lead to various changes in bacterial physiology including unstable folding of a quorum-sensing regulator. Indole appears to be responsible for acquisition of antibiotic resistance via the formation of persister cells and activation of an exporter. This review highlights and summarizes the current knowledge about indole as a multitrophic molecule among bacteria, together with recently identified new avenues of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.