ArticleEndocrine-related cancer2015
Magnetic resonance spectroscopy of paragangliomas: new insights into in vivo metabolomics.
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Article in Endocrine-related cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Metabolic Subtyping of Pheochromocytoma and Paraganglioma byJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- Prospective comparison of (68)Ga-DOTATATE and (18)F-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases.European journal of nuclear medicine and molecular imaging · 2016Trial
- Precision imaging and evolving therapies in paragangliomas and pheochromocytomas: from molecular diagnostics to imaging-guided management.Insights into imaging · 2026Article
- Imaging of Pheochromocytomas and Paragangliomas.Endocrine reviews · 2024Review
- Image-Guided Precision Medicine in the Diagnosis and Treatment of Pheochromocytomas and Paragangliomas.Cancers · 2023Review
- Metabolomics in paraganglioma: applications and perspectives from genetics to therapy.Endocrine-related cancer · 2023Article
- SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?Endocrine-related cancer · 2023Article
- Portocaval paraganglioma: A second case report.Annals of medicine and surgery (2012) · 2022Article
- Head and Neck Paragangliomas: An Update on the Molecular Classification, State-of-the-Art Imaging, and Management Recommendations.Radiology. Imaging cancer · 2022Review
- Comprehensive review of evaluation and management of cardiac paragangliomas.Heart (British Cardiac Society) · 2020Review
- Succinate detection using in vivoEuropean journal of nuclear medicine and molecular imaging · 2020Article
- Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.Clinical genetics · 2020Review
- Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2019Review
- TranslatingJCO precision oncology · 2018Article
- New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.Trends in endocrinology and metabolism: TEM · 2017Review
- The Evolving Role of Succinate in Tumor Metabolism: AnJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Article
- Implications of SDHB genetic testing in patients with sporadic pheochromocytoma.Langenbeck's archives of surgery · 2017Article
- Head-to-head comparison betweenEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.The Clinical biochemist. Reviews · 2017Review
- Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.Molecular genetics and metabolism reports · 2017Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Arthur VaroquauxDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France david.taieb@ap-hm.fr DamienArthur.VAROQUAUX@ap-hm.fr.
Yann le FurDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Alessio ImperialeDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France Department of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes o
Antony ReyreDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Marion MontavaDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Nicolas FakhryDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Izzie-Jacques NamerDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France Department of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes o
Guy MoulinDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Karel PacakDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France.
Maxime GuyeDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France Department of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes o
David TaïebDepartment of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Nuclear MedicineLa Timone University Hospital, Aix-Marseille University, Marseille, FranceBiophysics and Nuclear MedicineEuropean Center for Research in Medical Imaging, La Timone University Hospital, Aix-Marseille University, 264, Rue Saint-Pierre, 13385 Marseille, FranceINSERMUMR1068, Institut Paoli-Calmettes, Marseille Cancerology Research Center, Marseille, France Department of Medical ImagingLa Timone University Hospital, Aix-Marseille University, Marseille, FranceCNRSCRMBM UMR 7339, Aix-Marseille University, 13385 Marseille, FranceDepartment of Biophysics and Nuclear MedicineUniversity Hospitals of Strasbourg, Strasbourg, FranceICubeUMR 7357, Faculty of Medicine, University of Strasbourg/CNRS and FMTS, Strasbourg, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryNorth Hospital, Aix-Marseille University, Marseille, FranceDepartment of Otorhinolaryngology-Head and Neck SurgeryLa Timone University Hospital, Aix-Marseille University, Marseille, FranceProgram in Reproductive and Adult Endocrinology<ce:italic>Eunice Kennedy Shriver</ce:italic> National Institute of Child Health and Human Development (NICHD), National Institutes o
Aix-Marseille Université · FRCentre National de la Recherche Scientifique · FRHôpital de la Timone · FRCentre de Résonance Magnétique Biologique et Médicale · FR
Funding
Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4MIntramural NIH HHS ZIA HD008735
Abstract
Paragangliomas (PGLs) can be associated with mutations in genes of the tricarboxylic acid (TCA) cycle. Succinate dehydrogenase (SDHx) mutations are the prime examples of genetically determined TCA cycle defects with accumulation of succinate. Succinate, which acts as an oncometabolite, can be detected by ex vivo metabolomics approaches. The aim of this study was to evaluate the potential role of proton magnetic resonance (MR) spectroscopy ((1)H-MRS) for identifying SDHx-related PGLs in vivo and noninvasively. Eight patients were prospectively evaluated with single voxel (1)H-MRS. MR spectra from eight tumors (four SDHx-related PGLs, two sporadic PGLs, one cervical schwannoma, and one cervical neurofibroma) were acquired and interpreted qualitatively. Compared to other tumors, a succinate resonance peak was detected only in SDHx-related tumor patients. Spectra quality was considered good in three cases, medium in two cases, poor in two cases, and uninterpretable in the latter case. Smaller lesions had lower spectra quality compared to larger lesions. Jugular PGLs also exhibited a poorer spectra quality compared to other locations. (1)H-MRS has always been challenging in terms of its technical requisites. This is even more true for the evaluation of head and neck tumors. However, (1)H-MRS might be added to the classical MR sequences for metabolomic characterization of PGLs. In vivo detection of succinate might guide genetic testing, characterize SDHx variants of unknown significance (in the absence of available tumor sample), and even optimize a selection of appropriate therapies.
Indexed as
AdultAgedFemaleHumansMaleMetabolomicsMiddle AgedParagangliomaProton Magnetic Resonance SpectroscopySuccinate DehydrogenaseTumor BurdenSuccinate DehydrogenasemetabolomicsMR-spectroscopyparagangliomapositron-emission tomography
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