ArticleBMC complementary and alternative medicine2015
Evaluation of analgesic, anti-inflammatory, anti-depressant and anti-coagulant properties of Lactuca sativa (CV. Grand Rapids) plant tissues and cell suspension in rats.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Oilseed Cakes: A Promising Source of Antioxidant, and Anti-Inflammatory Agents-Insights fromInternational journal of molecular sciences · 2024Article
- Agrobacterium-Mediated Genetic Transformation ofACS omega · 2023Article
- Aquaphotomics Monitoring of Lettuce Freshness during Cold Storage.Foods (Basel, Switzerland) · 2023Article
- In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa.BMC complementary medicine and therapies · 2022Article
- Polyphenol RichMolecules (Basel, Switzerland) · 2021Article
- Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice.Plants (Basel, Switzerland) · 2020Article
- Sedative Effects of Latexes Obtained from SomeMolecules (Basel, Switzerland) · 2020Article
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- The Health Promoting Bioactivities ofMetabolites · 2019Article
- Neuroprotective, antidiabetic and antioxidant effect of Hedera nepalensis and lupeol against STZ + AlClDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2018Article
- New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine.Integrative medicine research · 2018Review
- Five Indigenous Plants of Pakistan with Antinociceptive, Anti-Inflammatory, Antidepressant, and Anticoagulant Properties in Sprague Dawley Rats.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities.BMC complementary and alternative medicine · 2016Article
- Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats.Avicenna journal of phytomedicineArticle
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLactuca sativa (lettuce) has been traditionally used for relieving pain, inflammation, stomach problems including indigestion and lack of appetite. Moreover, the therapeutic significance of L. sativa includes its anticonvulsant, sedative-hypnotic and antioxidant properties.
methodsIn the present study, the MC (methanol and chloroform; 1:1) and aqueous extracts of seed and leaf along with cell suspension exudate were prepared. These extracts were explored for their analgesic, anti-inflammatory, antidepressant and anticoagulant effects by hot plate analgesic assay; carrageenan induced hind paw edema test, forced swimming test and capillary method for blood clotting respectively in a rat model. The results were analyzed using one-way Analysis of Variance (ANOVA) followed by Turkey multiple comparison test.
resultsInterestingly, the extracts and the cell suspension exudate showed dual inhibition by reducing pain and inflammation. The results indicated that the aqueous extracts of leaf exhibited highest analgesic and anti-inflammatory activities followed by leaf MC, cell suspension exudate, seed aqueous and seed MC extracts. The current findings show that aqueous and MC extracts of seed have the least immobility time in the forced swimming test, which could act as an anti-depressant on the central nervous system. The leaf extracts and cell suspension exudate also expressed moderate anti-depressant activities. In anticoagulant assay, the coagulation time of aspirin (positive control) and MC extract of leaf was comparable, suggesting strong anti-coagulant effect. Additionally, no abnormal behavior or lethality was observed in any animal tested.
conclusionTaken together, L. sativa can potentially act as a strong herbal drug due to its multiple pharmaceutical effects and is therefore of interest in drug discovery and development of formulations.
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