ArticleBMC genomics2015
Core oxidative stress response in Aspergillus nidulans.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Low-Intensity, Short-Duration Proton Irradiation Enhances Oxidative Stress Sensitivity ofJournal of fungi (Basel, Switzerland) · 2026Article
- The photolyase/cryptochrome of Aspergillus nidulans senses oxidative stress and shuttles from nuclei to mitochondria.Nature communications · 2026Article
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- Global Transcriptomic Changes Elicited byJournal of fungi (Basel, Switzerland) · 2023Article
- Species-specific effects of the introduction of Aspergillus nidulans gfdB in osmophilic aspergilli.Applied microbiology and biotechnology · 2023Article
- Genome-Wide Gene Expression Analyses of the AtfA/AtfB-Mediated Menadione Stress Response inCells · 2023Article
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- Stress Responses Elicited by Glucose Withdrawal inJournal of fungi (Basel, Switzerland) · 2022Article
- Regulation of Conidiogenesis inCells · 2022Review
- bZIP transcription factors PcYap1 and PcRsmA link oxidative stress response to secondary metabolism and development in Penicillium chrysogenum.Microbial cell factories · 2022Article
- Functional analysis of the bZIP-type transcription factors AtfA and AtfB inFrontiers in microbiology · 2022Article
- Study on the bZIP-Type Transcription Factors NapA and RsmA in the Regulation of Intracellular Reactive Species Levels and Sterigmatocystin Production ofInternational journal of molecular sciences · 2021Article
- The impact of bZIP Atf1ortholog global regulators in fungi.Applied microbiology and biotechnology · 2021Review
- AtfA-Independent Adaptation to the Toxic Heavy Metal Cadmium inMicroorganisms · 2021Article
- The DUG Pathway Governs Degradation of Intracellular Glutathione in Aspergillus nidulans.Applied and environmental microbiology · 2021Article
- Quorum sensing-mediated inter-specific conidial anastomosis tube fusion between Colletotrichum gloeosporioides and C. siamense.IMA fungus · 2021Article
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- Two NewG3 (Bethesda, Md.) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe b-Zip transcription factor AtfA plays a key role in regulating stress responses in the filamentous fungus Aspergillus nidulans. To identify the core regulons of AtfA, we examined genome-wide expression changes caused by various stresses in the presence/absence of AtfA using A. nidulans microarrays. We also intended to address the intriguing question regarding the existence of core environmental stress response in this important model eukaryote.
resultsExamination of the genome wide expression changes caused by five different oxidative stress conditions in wild type and the atfA null mutant has identified a significant number of stereotypically regulated genes (Core Oxidative Stress Response genes). The deletion of atfA increased the oxidative stress sensitivity of A. nidulans and affected mRNA accumulation of several genes under both unstressed and stressed conditions. The numbers of genes under the AtfA control appear to be specific to a stress-type. We also found that both oxidative and salt stresses induced expression of some secondary metabolite gene clusters and the deletion of atfA enhanced the stress responsiveness of additional clusters. Moreover, certain clusters were down-regulated by the stresses tested.
conclusionOur data suggest that the observed co-regulations were most likely consequences of the overlapping physiological effects of the stressors and not of the existence of a general environmental stress response. The function of AtfA in governing various stress responses is much smaller than anticipated and/or other regulators may play a redundant or overlapping role with AtfA. Both stress inducible and stress repressive regulations of secondary metabolism seem to be frequent features in A. nidulans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.