ArticleBone2015
Abdominal aortic calcification and risk of fracture among older women - The SOF study.
Article in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Abdominal aortic calcification and the risk of bone fractures: a meta-analysis of prospective cohort studies.Journal of bone and mineral metabolism · 2018Pooled it
- Diabetes and Abdominal Aortic Calcification-a Systematic Review.Current osteoporosis reports · 2018Pooled it
- Abdominal aortic calcification and skeletal outcomes in hospitalized patients with surgically treated fragility fractures: a retrospective cohort study.Archives of osteoporosis · 2026Article
- Abdominal aortic calcification is associated with hip fracture in the elderly.Scientific reports · 2026Article
- Automated abdominal aortic calcification and trabecular bone score independently predict incident fracture during routine osteoporosis screening.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Abdominal aortic calcification as an opportunistic marker of reduced CT-derived vertebral bone density in osteoporotic vertebral fractures.Brain & spine · 2026Article
- Construction and validation of a risk prediction model for extensive abdominal aortic calcification in hypertensive patients aged 40 and above: a cross-sectional study based on the 2013-2014 NHANES database.BMC cardiovascular disorders · 2025Article
- Systematic evaluation of abdominal aortic calcification in patients with a recent clinical fracture visiting the Fracture Liaison Service.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Association between the atherogenic index of plasma and abdominal aortic calcification in adults: a cross-sectional study.BMC public health · 2024Article
- Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Association between serum estradiol levels and abdominal aortic calcification in postmenopausal woman: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Bone-derived PDGF-BB drives brain vascular calcification in male mice.The Journal of clinical investigation · 2023Article
- Abdominal aortic calcification assessed on standard lateral lumbar radiographs as a screening tool for impaired bone status in spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Skeletal and extraskeletal disorders of biomineralization.Nature reviews. Endocrinology · 2022Review
- Association between a body shape index and abdominal aortic calcification in general population: A cross-sectional study.Frontiers in cardiovascular medicine · 2022Article
- Abdominal aortic calcification (AAC) and ankle-brachial index (ABI) predict health care costs and utilization in older men, independent of prevalent clinical cardiovascular disease and each other.Atherosclerosis · 2020Observational
- Predictors of Imminent Risk of Nonvertebral Fracture in Older, High-Risk Women: The Framingham Osteoporosis Study.JBMR plus · 2019Article
- Article
- Carotid artery plaque screening using abdominal aortic calcification on lumbar radiographs.PloS one · 2019Article
- The associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 10 institutions in 3 countries.
Funding
Abstract
Data concerning the link between severity of abdominal aortic calcification (AAC) and fracture risk in postmenopausal women are discordant. This association may vary by skeletal site and duration of follow-up. Our aim was to assess the association between the AAC severity and fracture risk in older women over the short- and long term. This is a case-cohort study nested in a large multicenter prospective cohort study. The association between AAC and fracture was assessed using Odds Ratios (OR) and 95% confidence intervals (95%CI) for vertebral fractures and using Hazard Risks (HR) and 95%CI for non-vertebral and hip fractures. AAC severity was evaluated from lateral spine radiographs using Kauppila's semiquantitative score. Severe AAC (AAC score 5+) was associated with higher risk of vertebral fracture during 4 years of follow-up, after adjustment for confounders (age, BMI, walking, smoking, hip bone mineral density, prevalent vertebral fracture, systolic blood pressure, hormone replacement therapy) (OR=2.31, 95%CI: 1.24-4.30, p<0.01). In a similar model, severe AAC was associated with an increase in the hip fracture risk (HR=2.88, 95%CI: 1.00-8.36, p=0.05). AAC was not associated with the risk of any non-vertebral fracture. AAC was not associated with the fracture risk after 15 years of follow-up. In elderly women, severe AAC is associated with higher short-term risk of vertebral and hip fractures, but not with the long-term risk of these fractures. There is no association between AAC and risk of non-vertebral-non-hip fracture in older women. Our findings lend further support to the hypothesis that AAC and skeletal fragility are related.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.