Evidence map›Paper›PMID 26115846›Full record

ArticleThe patient2016

What Matters to Women When Making Decisions About Breast Cancer Chemoprevention?

Kathryn A Martinez, Angela Fagerlin, Holly O Witteman, Christine Holmberg, Sarah T Hawley

Abstract read
In one paragraph

Article in The patient, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Can the General Public Be a Proxy for an "At-Risk" Group in a Patient Preference Study? A Disease Prevention Example in Rheumatoid Arthritis.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Family health history reporting is sensitive to small changes in wording.Genetics in medicine : official journal of the American College of Medical Genetics · 2016
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kathryn A MartinezAnn Arbor VA Center for Clinical Management Research, Building 16, 4th Floor, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA. katiemartinez@gmail.com.
Angela FagerlinAnn Arbor VA Center for Clinical Management Research, Building 16, 4th Floor, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA.
Holly O WittemanDepartment of Family and Emergency Medicine and Office of Education and Continuing Professional Development, Laval University, Quebec City, QC, Canada.
Christine HolmbergBerlin School of Public Health, Berlin, Germany.
Sarah T HawleyAnn Arbor VA Center for Clinical Management Research, Building 16, 4th Floor, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA.
VA Center for Clinical Management Research · USQuebec Research and Development Centre

Funding

Training / Career DevelopmentP50CA101451 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRECHER, VICTOR J · 2003 to 2012
$18.2M
IDENTIFY &REDUCE COGNITIVE BIASES OF DECISION AIDSR01CA087595 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI UBEL, PETER A · 2002 to 2011
$4.2M
NCI NIH HHS P50 CA101451NCI NIH HHS R01 CA087595NCI NIH HHS R01 CA87595
6 · The paper itself

Abstract

purposeDespite the effectiveness of chemoprevention (tamoxifen and raloxifene) in preventing breast cancer among women at high risk for the disease, uptake is low. The objective of this study was to determine the tradeoff preferences for various attributes associated with chemoprevention among women not currently taking the drugs.

methodsWe used rating-based conjoint analysis to evaluate the relative importance of a number of attributes associated with chemoprevention, including risk of side effects, drug effectiveness, time needed to take the drugs, and availability of a blood test to see if the drugs were working in an Internet sample of women. We generated mean importance values and part-worth utilities for all attribute levels associated with taking chemoprevention. We then used multivariable linear regression to examine attribute importance scores controlling for participant age, race, Hispanic ethnicity, educational level, and a family history of breast cancer.

resultsOverall interest in taking chemoprevention was low among the 1094 women included in the analytic sample, even for the scenario in which participants would receive the greatest benefit and fewest risks associated with taking the drugs. Time needed to take the pill for it to work and 5-year risk of breast cancer were the most important attributes driving tradeoff preferences between the chemoprevention scenarios.

conclusionsInterest in taking chemoprevention among this sample of women at average risk was low. Addressing women's concerns about the time needed to take chemoprevention for it to work may help clinicians improve uptake of the drugs among those likely to benefit.

Indexed as

AdultBreast NeoplasmsChemopreventionDecision MakingEstrogen AntagonistsFemaleGuideline AdherenceHumansLinear ModelsMarketingMiddle AgedPatient Acceptance of Health CarePractice Guidelines as TopicRisk AssessmentTime FactorsUnited StatesEstrogen Antagonists

Identifiers

PMID26115846
PMCPMC5513503
OpenAlexW852089462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.