Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study.

Matthew G McCarroll, Mark S Riddle, Ramiro L Gutierrez, Chad K Porter

Abstract read

In one paragraph

Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

Indian consensus statements on irritable bowel syndrome in adults: A guideline by the Indian Neurogastroenterology and Motility Association and jointly supported by the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
Guideline
Post-infection Irritable Bowel Syndrome.Gastroenterology clinics of North America · 2021
Review
Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019
Review
Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review.World journal of gastroenterology · 2017
Review
Post-Infectious Irritable Bowel Syndrome.Current gastroenterology reports · 2017
Review
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link.Nature reviews. Gastroenterology & hepatology · 2017
Review
The Epidemiology of Irritable Bowel Syndrome in the US Military: Findings from the Millennium Cohort Study.The American journal of gastroenterology · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew G McCarrollDepartment of Epidemiology and Biostatistics, George Washington University, Washington, DC, 20037, USA.

Mark S RiddleEnteric Disease Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Ramiro L GutierrezEnteric Disease Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Chad K PorterEnteric Disease Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA. chad.k.porter2.civ@mail.mil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have linked an increase in functional and pathological gastrointestinal (GI) disorders following antecedent infectious gastroenteritis (IGE), yet studies of other chronic GI disorders such as tropical sprue (TS) and intestinal malabsorption (IM) are lacking. This study was performed to evaluate the association between documented IGE and the risk of TS and IM using a matched case-control study.

methodsThe odds of IGE (exposure) among subjects with TS and IM were compared to the odds of exposure in matched controls. Data were obtained from the Defense Medical Surveillance System. Incidence was estimated based on the number of active duty military personnel, and conditional logistic regression models were used to evaluate the relationship between IGE and TS/IM while adjusting for potential confounders.

resultsThe overall incidence of TS and IM was 0.24 and 1.98 per 100,000 person-years, respectively. After adjusting for important covariates, prior IGE was associated with an increase in the odds of TS (odds ratio (OR) 36.64) and IM (OR 3.93) (p < 0.001). Other covariates demonstrating an increased risk were being of Caucasian race, having greater than high school education, and service in military branches other than the Army.

conclusionOverall, this study demonstrates the first significant estimates that a case of antecedent IGE is associated with an increased risk of TS and IM in an active duty military population. Ultimately, acquisition of TS or IM has the potential to decrease operational efficiency, which may have a significant impact on deployed military missions.

Indexed as

Military MedicineAdultCase-Control StudiesDysenteryFemaleHumansIncidenceLogistic ModelsMalabsorption SyndromesMaleMilitary PersonnelMultivariate AnalysisOdds RatioRisk FactorsSprue, TropicalTime FactorsInfectious gastroenteritisIntestinal malabsorptionMilitaryTropical sprue

Identifiers

PMID26115751

DOI10.1007/s10620-015-3768-8

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.