ReviewExperimental eye research2015
Biomechanical assessment in models of glaucomatous optic neuropathy.
Review in Experimental eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Lamina cribrosa shape in non-human primates is different from that of humans.Experimental eye research · 2025Article
- High Myopia-Induced Optic Nerve Head Deformation and Glaucoma Progression: A Three-Year Follow-Up Study.Investigative ophthalmology & visual science · 2025Article
- Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases.Pharmaceutics · 2023Review
- Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis.Journal of cellular physiology · 2022Article
- Review
- Corneal Hysteresis in Thais and Variation of Corneal Hysteresis in Glaucoma.Clinical optometry · 2021Article
- OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness, and Minimum Cross-Sectional Area in Healthy Eyes.American journal of ophthalmology · 2019Article
- Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma.Medicine · 2019Observational
- [Structural endpoints for glaucoma studies].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Magnetic Resonance Conditional Microinjector.Journal of imaging · 2018Article
- Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues.Journal of biomedical optics · 2018Article
- Neuroprotective strategies for retinal disease.Progress in retinal and eye research · 2018Review
- Opto-mechanical characterization of sclera by polarization sensitive optical coherence tomography.Journal of biomechanics · 2018Article
- In Vivo Small Molecule Delivery to the Optic Nerve in a Rodent Model.Scientific reports · 2018Article
- Progressive Deformation of the Optic Nerve Head and Peripapillary Structures by Graded Horizontal Duction.Investigative ophthalmology & visual science · 2017Article
- Finite Element Biomechanics of Optic Nerve Sheath Traction in Adduction.Journal of biomechanical engineering · 2017Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
- Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation.Scientific reports · 2016Article
- Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.Journal of biomechanical engineering · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The biomechanical environment within the eye is of interest in both the regulation of intraocular pressure and the loss of retinal ganglion cell axons in glaucomatous optic neuropathy. Unfortunately, this environment is complex and difficult to determine. Here we provide a brief introduction to basic concepts of mechanics (stress, strain, constitutive relationships) as applied to the eye, and then describe a variety of experimental and computational approaches used to study ocular biomechanics. These include finite element modeling, direct experimental measurements of tissue displacements using optical and other techniques, direct experimental measurement of tissue microstructure, and combinations thereof. Thanks to notable technical and conceptual advances in all of these areas, we are slowly gaining a better understanding of how tissue biomechanical properties in both the anterior and posterior segments may influence the development of, and risk for, glaucomatous optic neuropathy. Although many challenging research questions remain unanswered, the potential of this body of work is exciting; projects underway include the coupling of clinical imaging with biomechanical modeling to create new diagnostic tools, development of IOP control strategies based on improved understanding the mechanobiology of the outflow tract, and attempts to develop novel biomechanically-based therapeutic strategies for preservation of vision in glaucoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.