ArticleJournal of psychosomatic research2015
The development of depressive symptoms during medical internship stress predicts worsening vascular function.
Article in Journal of psychosomatic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force.Bipolar disorders · 2026Review
- Duration of New-Onset Depressive Symptoms During Medical Residency.JAMA network open · 2024Article
- Cerebrovascular reactivity is blunted in young adults with major depressive disorder: The influence of current depressive symptomology.Journal of affective disorders · 2021Article
- Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder.Scientific reports · 2021Article
- Advances of Endothelial Progenitor Cells in the Development of Depression.Frontiers in cellular neuroscience · 2021Review
- Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.Journal of the American Heart Association · 2020Article
- Insomnia symptoms and short sleep predict anxiety and worry in response to stress exposure: a prospective cohort study of medical interns.Sleep medicine · 2019Article
- Self-Reported Everyday Psychosocial Stressors Are Associated With Greater Impairments in Endothelial Function in Young Adults With Major Depressive Disorder.Journal of the American Heart Association · 2019Article
- Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder.Circulation research · 2019Article
- Inflammatory and vascular correlates of mood change over 8 weeks.Heart and mind (Mumbai, India)Article
- Bipolar disorder and related mood states are not associated with endothelial function of small arteries in adults without heart disease.General hospital psychiatryArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveWe sought to prospectively determine whether the onset of internship stress and any subsequent depression alters physiological markers of early vascular disease
methodsWe explored potential mechanisms linking stress and depression to vascular disease in a prospective cohort of 37 participants exposed to medical internship stress, an established precipitant of depressive symptomatology.
resultsChange in depressive symptom score from baseline over one year of internship stress was inversely correlated with change in the reactive hyperemia index (RHI), a measure of peripheral endothelial function (r=0.41, p=0.01). The change in depressive symptoms in the first six months of internship was similarly related to change in RHI over one year (r=0.38, p=0.02). While the development of depressive symptoms did not significantly impact changes in endothelial progenitor cells (EPCs), EPCs did significantly decrease with the year of internship stress (11.9 to 3.4cells/ml blood; p=0.01).
conclusionEndothelial function may be a critical link between stress, depression, and cardiovascular disease and a feasible surrogate outcome for prospective studies.
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