ArticleNeurobiology of aging2015
Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- (Dis-)Connected Dots in Dementia with Lewy Bodies-A Systematic Review of Connectivity Studies.Movement disorders : official journal of the Movement Disorder Society · 2023Pooled it
- Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Microstructural white matter alterations in dementia with lewy bodies and Alzheimer's disease: a diffusion tensor imaging and neurite orientation dispersion and density imaging study.Frontiers in aging neuroscience · 2026Article
- Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.Alzheimer's research & therapy · 2025Article
- Damage Resistance of an fMRI-Spiking Neural Network Based on Speech Recognition Against Stochastic Attack.Biomimetics (Basel, Switzerland) · 2025Article
- Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment.Pharmaceutics · 2025Review
- EEG reveals brain network alterations in chronic aphasia during natural speech listening.Scientific reports · 2025Article
- Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome.Scientific reports · 2025Article
- EEG-based minimum spanning tree analysis reveals network disruptions in Alzheimer's disease spectrum: an observational study.Frontiers in aging neuroscience · 2025Article
- Attention Network Dysfunctions in Lewy Body Dementia and Alzheimer's Disease.Journal of clinical medicine · 2024Article
- Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology · 2022Review
- Reorganization of rich clubs in functional brain networks of dementia with Lewy bodies and Alzheimer's disease.NeuroImage. Clinical · 2022Article
- Altered resting state brain metabolic connectivity in dementia with Lewy bodies.Frontiers in neurology · 2022Article
- Dynamics of the Brain Functional Network Associated With Subjective Cognitive Decline and Its Relationship to Apolipoprotein E €4 Alleles.Frontiers in aging neuroscience · 2022Article
- Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Review
- The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration.Communications biology · 2021Article
- Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Reconfiguration of Dynamic Functional Connectivity States in Patients With Lifelong Premature Ejaculation.Frontiers in neuroscience · 2021Article
- Impaired sensory evidence accumulation and network function in Lewy body dementia.Brain communications · 2021Article
- The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline.Translational neurodegeneration · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer's disease (AD), suggesting a divergence between these diseases in terms of brain network organization. To fully understand this, we studied functional networks from resting-state functional magnetic resonance imaging in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared with the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD < controls < DLB), and this was also the case for global efficiency (DLB > controls > AD) and clustering coefficient (DLB < controls < AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.