ArticlePloS one2015
Effects of 1-Methylnicotinamide (MNA) on Exercise Capacity and Endothelial Response in Diabetic Mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial.European journal of applied physiology · 2019Trial
- Circulating 1-Methylnicotinamide Predicts Dupilumab Response in Adult Asthma: A Prediction Model.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Four key inflammatory pathways and targets in diabetic foot ulcers explored through data-driven analysis.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
- Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target.Biomolecules · 2025Review
- Exploring NNMT: from metabolic pathways to therapeutic targets.Archives of pharmacal research · 2024Review
- Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome.Frontiers in pharmacology · 2024Review
- Training-induced impairment of endothelial function in track and field female athletes.Scientific reports · 2023Article
- Article
- Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes.BioMed research international · 2021Review
- Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.Redox biology · 2020Article
- Comparison of Pulmonary and Systemic NO- and PGIOxidative medicine and cellular longevity · 2018Article
- Effects of chronic nitric oxide synthase inhibition on V'ONaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Fluid shear stress induces upregulation of COX-2 and PGIAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression.American journal of cancer research · 2017Article
- Functional and Biochemical Endothelial ProfilingFrontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1-Methylnicotinamide (MNA), which was initially considered to be a biologically inactive endogenous metabolite of nicotinamide, has emerged as an anti-thrombotic and anti-inflammatory agent with the capacity to release prostacyclin (PGI2). In the present study, we characterized the effects of MNA on exercise capacity and the endothelial response to exercise in diabetic mice. Eight-week-old db/db mice were untreated or treated with MNA for 4 weeks (100 mg·kg-1), and their exercise capacity as well as NO- and PGI2-dependent response to endurance running were subsequently assessed. MNA treatment of db/db mice resulted in four-fold and three-fold elevation of urine concentrations of MNA and its metabolites (Met-2PY + Met-4PY), respectively (P<0.01), but did not affect HbA1c concentration, fasting glucose concentration or lipid profile. However, insulin sensitivity was improved (P<0.01). In MNA-treated db/db mice, the time to fatigue for endurance exercise was significantly prolonged (P<0.05). Post-exercise Δ6-keto-PGF1α (difference between mean concentration in the sedentary and exercised groups) tended to increase, and post-exercise leukocytosis was substantially reduced in MNA-treated animals. In turn, the post-exercise fall in plasma concentration of nitrate was not affected by MNA. In conclusion, we demonstrated for the first time that MNA improves endurance exercise capacity in mice with diabetes, and may also decrease the cardiovascular risk of exercise.
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