ArticleStress (Amsterdam, Netherlands)2015
HPA-axis stress reactivity in youth depression: evidence of impaired regulatory processes in depressed boys.
Article in Stress (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Does Emotional Intelligence Buffer the Effects of Acute Stress? A Systematic Review.Frontiers in psychology · 2019Pooled it
- Is HPA axis reactivity in childhood gender-specific? A systematic review.Biology of sex differences · 2017Pooled it
- Early life stress sensitizes youth to the influence of stress-induced cortisol on memory for affective words.Developmental psychobiology · 2021Trial
- Exploration of wearable sensor measures associated with panic attacks differs across mental health conditions.Frontiers in digital health · 2026Article
- From Better Sleep to Improved Mood: A Review of the Biopsychosocial Pathways for Cognitive Behavioral Therapy for Insomnia's Antidepressant Effects.Current sleep medicine reports · 2026Review
- Restoration of typical HPA-SAM co-activation following psychosocial intervention among preadolescent youth living in poverty.Development and psychopathology · 2025Article
- Psychobiological Stress Response Profiles in Current and Remitted Depression: A Person-Centered, Multisystem Approach.Biological psychiatry global open science · 2025Article
- Association between Hpa Axis Functioning and Mental Health in Maltreated Children and Adolescents: A Systematic Literature Review.Children (Basel, Switzerland) · 2023Review
- HPA-SAM co-activation among racially diverse, economically disadvantaged early adolescents: Secondary analysis with a preliminary test of a multisystem, person-centered approach.Biological psychology · 2023Article
- Cortisol Reactivity as a Mediator of Peer Victimization on Child Internalizing and Externalizing Problems: The Role of Gender Differences.Research on child and adolescent psychopathology · 2022Article
- A multiple levels of analysis examination of the performance goal model of depression vulnerability in preadolescent children.Development and psychopathology · 2022Observational
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Integration of the Cortical Haemodynamic Response Measured by Functional Near-Infrared Spectroscopy and Amino Acid Analysis to Aid in the Diagnosis of Major Depressive Disorder.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Giving Voice to Vulnerable Children: Machine Learning Analysis of Speech Detects Anxiety and Depression in Early Childhood.IEEE journal of biomedical and health informatics · 2019Article
- Cognitive reappraisal attenuates the association between depressive symptoms and emotional response to stress during adolescence.Cognition & emotion · 2019Article
- Validating a Self-Report Measure of Student Athletes' Perceived Stress Reactivity: Associations With Heart-Rate Variability and Stress Appraisals.Frontiers in psychology · 2019Article
- A Path Analysis of Adolescent Athletes' Perceived Stress Reactivity, Competition Appraisals, Emotions, Coping, and Performance Satisfaction.Frontiers in psychology · 2019Article
- Hormonal Cycles, Brain Network Connectivity, and Windows of Vulnerability to Affective Disorder.Trends in neurosciences · 2018Review
- FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study.Journal of psychiatric research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Given the link between youth depression and stress exposure, efforts to identify related biomarkers have involved examinations of stress regulation systems, including the hypothalamic-pituitary-adrenal (HPA) axis. Despite these vast efforts, the underlying mechanisms at play, as well as factors that may explain heterogeneity of past findings, are not well understood. In this study, we simultaneously examined separate components of the HPA-axis response (e.g. activation intensity, peak levels, recovery) to the Socially Evaluated Cold-Pressor Test in a targeted sample of 115 youth (age 9-16), recruited to overrepresent youth with elevated symptoms of depression. Among youth who displayed a cortisol response to the task, depression symptoms were associated with higher peak responses but not greater rate of activation or recovery in boys only. Among those who did not respond to the task, depression symptoms were associated with greater cortisol levels throughout the visit in boys and girls. Results suggest that depression symptoms are associated with a more prolonged activation of the axis and impaired recovery to psychosocial stressors primarily in boys. We discussed two potential mechanistic explanations of the link between depression symptoms and the duration of activation: (1) inhibitory shift (i.e. point at which the ratio of inhibitory and excitatory input into the axis shifts from greater excitatory to greater inhibitory input) or (2) inhibitory threshold (i.e. level of cortisol exposure required to activate the axis' feedback inhibition system).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.