ArticleActa psychiatrica Scandinavica2016
Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder.
Article in Acta psychiatrica Scandinavica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 60 citations in OpenAlex.
- Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial.The Journal of clinical psychiatryTrial
- Controversies regarding lithium-associated weight gain: case-control study of real-world drug safety data.International journal of bipolar disorders · 2023Article
- Prediction of the Duration to Next Admission for an Acute Affective Episode in Patients with Bipolar I Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Clinical, Economic, and Humanistic Outcomes Associated with Obesity Among People with Bipolar I Disorder in the United States: Analysis of National Health and Wellness Survey Data.ClinicoEconomics and outcomes research : CEOR · 2023Article
- The genetics of bipolar disorder with obesity and type 2 diabetes.Journal of affective disorders · 2022Review
- Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies.Journal of affective disorders · 2022Article
- Metabolic Syndrome Impairs Executive Function in Bipolar Disorder.Frontiers in neuroscience · 2021Article
- Call to action regarding the vascular-bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders.Bipolar disorders · 2020Review
- Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.BMC psychiatry · 2020Article
- Obesity in Adolescents with Psychiatric Disorders.Current psychiatry reports · 2019Review
- Bipolar Disorder and Obesity: Contributing Factors, Impact on Clinical Course, and the Role of Bariatric Surgery.Current obesity reports · 2018Review
- Dietary influences on cognition.Physiology & behavior · 2018Article
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 1 country.
Funding
Abstract
objectiveExamine the effects of obesity and metabolic syndrome on outcome in bipolar disorder.
methodThe Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer and a Classic Mood Stabilizer for Bipolar Disorder (Bipolar CHOICE) study randomized 482 participants with bipolar disorder in a 6-month trial comparing lithium- and quetiapine-based treatment. Baseline variables were compared between groups with and without obesity, with and without abdominal obesity, and with and without metabolic syndrome respectively. The effects of baseline obesity, abdominal obesity, and metabolic syndrome on outcomes were examined using mixed effects linear regression models.
resultsAt baseline, 44.4% of participants had obesity, 48.0% had abdominal obesity, and 27.3% had metabolic syndrome; neither obesity, nor abdominal obesity, nor metabolic syndrome were associated with increased global severity, mood symptoms, or suicidality, or with poorer functioning or life satisfaction. Treatment groups did not differ on prevalence of obesity, abdominal obesity, or metabolic syndrome. By contrast, among the entire cohort, obesity was associated with less global improvement and less improvement in total mood and depressive symptoms, suicidality, functioning, and life satisfaction after 6 months of treatment. Abdominal obesity was associated with similar findings. Metabolic syndrome had no effect on outcome.
conclusionObesity and abdominal obesity, but not metabolic syndrome, were associated with less improvement after 6 months of lithium- or quetiapine-based treatment.
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Registered trials
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