ArticlePloS one2015
Streptococcus oligofermentans Inhibits Streptococcus mutans in Biofilms at Both Neutral pH and Cariogenic Conditions.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A pilot study to assess oral colonization and pH buffering by the probiotic Streptococcus dentisani under different dosing regimes.Odontology · 2020Trial
- Topic Application of the ProbioticFrontiers in cellular and infection microbiology · 2020Trial
- Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Designing Highly Potent Side-Chain Lactam-Bridged Cyclic Competence-Stimulating Peptide-Based Quorum-Sensing Modulators inACS infectious diseases · 2025Article
- Streptococcus cristatus reduces cariogenicity of saliva-derived microcosms under pH-dependent conditions.Journal of oral microbiology · 2025Article
- Mechanism of Action ofAntibiotics (Basel, Switzerland) · 2023Article
- Elucidating the Role and Structure-Activity Relationships of theACS chemical biology · 2021Article
- In Vitro Anti-Biofilm and Antibacterial Properties ofMicroorganisms · 2021Article
- Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa.Contact dermatitis · 2020Article
- Environment-Specific Probiotic Supernatants Modify the Metabolic Activity and Survival ofFrontiers in microbiology · 2020Article
- Effect of Different Glucose Concentrations on Small RNA Levels and Adherence of Streptococcus mutans.Current microbiology · 2019Article
- Regrowth of Microcosm Biofilms on Titanium Surfaces After Various Antimicrobial Treatments.Frontiers in microbiology · 2019Article
- Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome.Molecular oral microbiology · 2018Review
- Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure.Applied and environmental microbiology · 2017Article
- Stress responses in Streptococcus species and their effects on the host.Journal of microbiology (Seoul, Korea) · 2015Review
- Anti-caries Streptococcus spp.: A potential preventive tool for special needs patients.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeostasis of oral microbiota can be maintained through microbial interactions. Previous studies showed that Streptococcus oligofermentans, a non-mutans streptococci frequently isolated from caries-free subjects, inhibited the cariogenic Streptococcus mutans by the production of hydrogen peroxide (HP). Since pH is a critical factor in caries formation, we aimed to study the influence of pH on the competition between S. oligofermentans and S. mutans in biofilms. To this end, S. mutans and S. oligofermentans were inoculated alone or mixed at 1:1 ratio in buffered biofilm medium in a 96-well active attachment model. The single- and dual-species biofilms were grown under either constantly neutral pH or pH-cycling conditions. The latter includes two cycles of 8 h neutral pH and 16 h pH 5.5, used to mimic cariogenic condition. The 48 h biofilms were analysed for the viable cell counts, lactate and HP production. The last two measurements were carried out after incubating the 48 h biofilms in buffers supplemented with 1% glucose (pH 7.0) for 4 h. The results showed that S. oligofermentans inhibited the growth of S. mutans in dual-species biofilms under both tested pH conditions. The lactic acid production of dual-species biofilms was significantly lower than that of single-species S. mutans biofilms. Moreover, dual-species and single-species S. oligofermentans biofilms grown under pH-cycling conditions (with a 16 h low pH period) produced a significantly higher amount of HP than those grown under constantly neutral pH. In conclusion, S. oligofermentans inhibited S. mutans in biofilms not only under neutral pH, but also under pH-cycling conditions, likely through HP production. S. oligofermentans may be a compelling probiotic candidate against caries.
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