ArticlePloS one2015
Genetic and Non-Genetic Inheritance of Natural Antibodies Binding Keyhole Limpet Hemocyanin in a Purebred Layer Chicken Line.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Strain-specific genetic relationships between Mycoplasma synoviae immunity and egg production traits in two layer lines.Poultry science · 2026Article
- Pasture vs. Coop: Biomarker Insights into Free-Range and Conventional Broilers.Animals : an open access journal from MDPI · 2024Article
- Genetic Variation in Natural and Induced Antibody Responses in Layer Chickens.Animals : an open access journal from MDPI · 2024Article
- The genetics of resilience and its relationships with egg production traits and antibody traits in chickens.Genetics, selection, evolution : GSE · 2024Article
- Antigen specificity affects analysis of natural antibodies.Frontiers in immunology · 2024Article
- Levels of Circulating IgM and IgY Natural Antibodies in Broiler Chicks: Association with Genotype and Farming Systems.Biology · 2023Article
- Genetic Analyses of Response of Local Ghanaian Tanzanian Chicken Ecotypes to a Natural Challenge with Velogenic Newcastle Disease Virus.Animals : an open access journal from MDPI · 2022Article
- Divergent selection for natural antibodies in poultry in the presence of a major gene.Genetics, selection, evolution : GSE · 2022Article
- Genetic and phenotypic correlations among feed efficiency, immune and production traits in indigenous chicken of Kenya.Frontiers in genetics · 2022Article
- Effects of eggshell temperature pattern during incubation on primary immune organ development and broiler immune response in later life.Poultry science · 2020Article
- The genetic basis of natural antibody titers of young healthy pigs and relationships with disease resilience.BMC genomics · 2020Article
- Impact of Housing Environment on the Immune System in Chickens: A Review.Animals : an open access journal from MDPI · 2020Review
- Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.PLoS biology · 2020Article
- Early-life microbiota transplantation affects behavioural responses, serotonin and immune characteristics in chicken lines divergently selected on feather pecking.Scientific reports · 2020Article
- Current Understanding of Natural Antibodies and Exploring the Possibilities of Modulation Using Veterinary Models. A Review.Frontiers in immunology · 2020Review
- Does paternal immunocompetence affect offspring vulnerability to maternal androgens? A study in domestic chickens.Biology open · 2019Article
- Maternal Transfer of Natural (Auto-) Antibodies in Chickens.Poultry science · 2019Article
- Body Weight Deviations as Indicator for Resilience in Layer Chickens.Frontiers in genetics · 2019Article
- A genome-wide association study for natural antibodies measured in blood of Canadian Holstein cows.BMC genomics · 2018Article
- Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies.Frontiers in immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural antibodies (NAb) are defined as antibodies present in individuals without known antigenic challenge. Levels of NAb binding keyhole limpet hemocyanin (KLH) in chickens were earlier shown to be heritable, and to be associated with survival. Selective breeding may thus provide a strategy to improve natural disease resistance. We phenotyped 3,689 white purebred laying chickens for KLH binding NAb of different isotypes around 16 weeks of age. Heritabilities of 0.12 for the titers of total antibodies (IgT), 0.14 for IgM, 0.10 for IgA, and 0.07 for IgG were estimated. We also estimated high, positive genetic, and moderate to high, positive phenotypic correlations of IgT, IgM, IgA, and IgG, suggesting that selective breeding for NAb can be done on all antibody isotypes simultaneously. In addition, a relatively substantial non-genetic maternal environmental effect of 0.06 was detected for IgM, which may reflect a transgenerational effect. This suggests that not only the genes of the mother, but also the maternal environment affects the immune system of the offspring. Breaking strength and early eggshell whiteness of the mother's eggs were predictive for IgM levels in the offspring, and partly explained the observed maternal environmental effects. The present results confirm that NAb are heritable, however maternal effects should be taken into account.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.