ArticlePLoS genetics2015
Separable Crossover-Promoting and Crossover-Constraining Aspects of Zip1 Activity during Budding Yeast Meiosis.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3.Genetics · 2026Article
- Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3.bioRxiv : the preprint server for biology · 2025Article
- Improved synapsis dynamics accompany meiotic stability inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries.Trends in genetics : TIG · 2025Review
- Suppression of meiotic crossovers in pericentromeric heterochromatin requires synaptonemal complex and meiotic recombination factors inbioRxiv : the preprint server for biology · 2024Article
- Proximity labeling reveals new functional relationships between meiotic recombination proteins in S. cerevisiae.PLoS genetics · 2024Article
- Article
- Meiosis in budding yeast.Genetics · 2023Article
- Learning to tango with four (or more): the molecular basis of adaptation to polyploid meiosis.Plant reproduction · 2023Review
- Lessons from the meiotic recombination landscape of the ZMM deficient budding yeast Lachancea waltii.PLoS genetics · 2023Article
- ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction.Nucleic acids research · 2022Article
- Histone variant H2A.Z promotes meiotic chromosome axis organization in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2022Article
- Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A role for synaptonemal complex in meiotic mismatch repair.Genetics · 2022Article
- The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly.Genes & development · 2022Article
- The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation.Nucleic acids research · 2021Article
- Rewiring Meiosis for Crop Improvement.Frontiers in plant science · 2021Review
- Meiotic Crossover Patterning.Frontiers in cell and developmental biology · 2021Review
- Sharing Marks: H3K4 Methylation and H2B Ubiquitination as Features of Meiotic Recombination and Transcription.International journal of molecular sciences · 2020Review
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Accurate chromosome segregation during meiosis relies on the presence of crossover events distributed among all chromosomes. MutSγ and MutLγ homologs (Msh4/5 and Mlh1/3) facilitate the formation of a prominent group of meiotic crossovers that mature within the context of an elaborate chromosomal structure called the synaptonemal complex (SC). SC proteins are required for intermediate steps in the formation of MutSγ-MutLγ crossovers, but whether the assembled SC structure per se is required for MutSγ-MutLγ-dependent crossover recombination events is unknown. Here we describe an interspecies complementation experiment that reveals that the mature SC is dispensable for the formation of Mlh3-dependent crossovers in budding yeast. Zip1 forms a major structural component of the budding yeast SC, and is also required for MutSγ and MutLγ-dependent crossover formation. Kluyveromyces lactis ZIP1 expressed in place of Saccharomyces cerevisiae ZIP1 in S. cerevisiae cells fails to support SC assembly (synapsis) but promotes wild-type crossover levels in those nuclei that progress to form spores. While stable, full-length SC does not assemble in S. cerevisiae cells expressing K. lactis ZIP1, aggregates of K. lactis Zip1 displayed by S. cerevisiae meiotic nuclei are decorated with SC-associated proteins, and K. lactis Zip1 promotes the SUMOylation of the SC central element protein Ecm11, suggesting that K. lactis Zip1 functionally interfaces with components of the S. cerevisiae synapsis machinery. Moreover, K. lactis Zip1-mediated crossovers rely on S. cerevisiae synapsis initiation proteins Zip3, Zip4, Spo16, as well as the Mlh3 protein, as do the crossovers mediated by S. cerevisiae Zip1. Surprisingly, however, K. lactis Zip1-mediated crossovers are largely Msh4/Msh5 (MutSγ)-independent. This separation-of-function version of Zip1 thus reveals that neither assembled SC nor MutSγ is required for Mlh3-dependent crossover formation per se in budding yeast. Our data suggest that features of S. cerevisiae Zip1 or of the assembled SC in S. cerevisiae normally constrain MutLγ to preferentially promote resolution of MutSγ-associated recombination intermediates.
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