ArticleNanoscale2015
Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles.
Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Article
- Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins without Resolution Loss: Access to Short-Lived Intermediates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules.The journal of physical chemistry letters · 2025Article
- Advances in silica nanoparticles for agricultural applications and biosynthesis.Advanced biotechnology · 2025Review
- The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies byAnalytical chemistry · 2025Article
- Exploiting Silica-Binding and Silica-Forming Proteins as Versatile Tools for One-Step Enzyme Immobilization on Siliceous Materials.International journal of molecular sciences · 2025Review
- Nanoengineered Silica-Based Biomaterials for Regenerative Medicine.International journal of molecular sciences · 2024Review
- Construction of mannose-modified polyethyleneimine-block-polycaprolactone cationic polymer micelles and its application in acute lung injury.Drug delivery and translational research · 2022Article
- Diatom-inspired multiscale mineralization of patterned protein-polysaccharide complex structures.National science review · 2021Article
- Self-Assembly of Elastin-like Polypeptide Brushes on Silica Surfaces and Nanoparticles.Biomacromolecules · 2021Article
- Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly.Advanced therapeutics · 2020Article
- Kinetics of fluoride-catalysed synthesis of organosilica colloids in aqueous solutions of amphiphiles.RSC advances · 2019Article
- Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis.Asian journal of pharmaceutical sciences · 2019Article
- Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.Biomacromolecules · 2018Article
- Modular protein domains: an engineering approach toward functional biomaterials.Current opinion in biotechnology · 2016Review
- Silaffins in Silica Biomineralization and Biomimetic Silica Precipitation.Marine drugs · 2015Review
- Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The programmed self-assembly of block copolymers into higher order nanoscale structures offers many attractive attributes for the development of new nanomaterials for numerous applications including drug delivery and biosensing. The incorporation of biomimetic silaffin peptides in these block copolymers enables the formation of hybrid organic-inorganic materials, which can potentially enhance the utility and stability of self-assembled nanostructures. We demonstrate the design, synthesis and characterization of amphiphilic elastin-like polypeptide (ELP) diblock copolymers that undergo temperature-triggered self-assembly into well-defined spherical micelles. Genetically encoded incorporation of the silaffin R5 peptide at the hydrophilic terminus of the diblock ELP leads to presentation of the silaffin R5 peptide on the coronae of the micelles, which results in localized condensation of silica and the formation of near-monodisperse, discrete, sub-100 nm diameter hybrid ELP-silica particles. This synthesis method, can be carried out under mild reaction conditions suitable for bioactive materials, and will serve as the basis for the development and application of functional nanomaterials. Beyond silicification, the general strategies described herein may also be adapted for the synthesis of other biohybrid nanomaterials as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.