ArticlePloS one2015
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Psychiatric research in the Northern Finland Birth Cohort 1986 - a systematic review.International journal of circumpolar health · 2019Pooled it
- Driven by Dopamine: Genetic Insights into Motivation and Performance in Sports and Esports.Genes · 2026Review
- Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction.BMC psychology · 2024Article
- Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2023Article
- Genetic analysis of suicide: a sample study in Tuscany (Central Italy).Forensic sciences research · 2022Article
- Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone.Frontiers in pharmacology · 2021Review
- The effect ofBrain and behavior · 2017Article
- Effects of dopamine D2/D3 receptor antagonism on human planning and spatial working memory.Translational psychiatry · 2017Article
- DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury.Neurogenetics · 2017Observational
- Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months.PloS one · 2017Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThere is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders.
methodsWe measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up.
resultsPrincipal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049).
conclusionThe effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis.
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