ArticleJournal of magnetic resonance imaging : JMRI2015
In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Patient-Specific Biases in Fat Fraction Estimates of Malignant Bone Marrow due to Relaxation Times Measured With STEAM at 3T.NMR in biomedicine · 2026Article
- Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.Magnetic resonance in medicine · 2026Article
- Multi-Parameter Magnetic Resonance Spectroscopy in Cervix.NMR in biomedicine · 2026Article
- Optimized acquisition for simultaneous intravoxel incoherent motion and RMagnetic resonance in medicine · 2025Article
- Whole liver phase-based R2 mapping in liver iron overload within a breath-hold.Magnetic resonance in medicine · 2025Article
- Confounder-corrected TMagnetic resonance in medicine · 2023Article
- Non-Invasive Imaging Methods to Evaluate Non-Alcoholic Fatty Liver Disease with Fat Quantification: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.Magnetic resonance in medicine · 2022Article
- Noninvasive assessment of steatosis and viability of cold-stored human liver grafts by MRI.Magnetic resonance in medicine · 2021Article
- Review
- Limits of Fat Quantification in the Presence of Iron Overload.Journal of magnetic resonance imaging : JMRI · 2021Article
- Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver.Magnetic resonance in medicine · 2021Article
- Applications of Non-invasive and Novel Methods of Low-Field Nuclear Magnetic Resonance and Magnetic Resonance Imaging in Aquatic Products.Frontiers in nutrition · 2021Review
- Motion-robust, high-SNR liver fat quantification using a 2D sequential acquisition with a variable flip angle approach.Magnetic resonance in medicine · 2020Article
- The relationship between liver triglyceride composition and proton density fat fraction as assessed byNMR in biomedicine · 2020Article
- Characterizing a short TMagnetic resonance in medicine · 2019Article
- Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise.Abdominal radiology (New York) · 2019Article
- Optimized Diffusion-Weighting Gradient Waveform Design (ODGD) formulation for motion compensation and concomitant gradient nulling.Magnetic resonance in medicine · 2019Article
- Mapping tissue water TNMR in biomedicine · 2019Article
- Stimulated echo based mapping (STEM) of TMagnetic resonance in medicine · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
purposeTo examine the intra-examination repeatability of proton density fat fraction (PDFF) and T1 and T2 of liver water and fat as estimated by a novel multi-repetition time (TR)-echo time (TE) (1) H magnetic resonance spectroscopy (MRS)-stimulated echo acquisition mode (STEAM) sequence that acquires 32 spectra for a range of TRs and TEs in single breath-hold. MATERIALS AND
methodsSixty-seven subjects undergoing liver MRI examinations at 3T had three multi-TR-TE sequences acquired consecutively in a single session. This sequence was designed to allow accurate estimation of T1 and T2 of both water and fat, as well as PDFF, in a single breath-hold. A standard long-TR, multi-TE sequence was also acquired to allow comparison of estimated PDFF. Regression and interclass correlation (ICC) analyses were performed.
resultsThere was strong agreement between PDFF estimated by the multi-TR-TE and long-TR, multi-TE sequences (slope 0.997; intercept -0.03; R = 0.997). The multi-TR-TE sequence had high repeatability for estimating PDFF (ICC = 0.999), water T2 (ICC = 0.920), water T1 (ICC = 0.845), and fat T2 (ICC = 0.760), and moderate repeatability for estimating fat T1 (ICC = 0.556).
conclusionA novel multi-TR-TE sequence can estimate PDFF and water and fat T1 and T2 in a single breath-hold. Refinement may be needed to improve repeatability for fat T1 estimation.
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