ArticlePLoS genetics2015
Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Evolution and regulation of animal sex chromosomes.Nature reviews. Genetics · 2025Review
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.Molecular biology and evolution · 2023Article
- Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation.Molecular ecology resources · 2022Article
- Chromatin landscape associated with sexual differentiation in a UV sex determination system.Nucleic acids research · 2022Article
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- PromethION Sequencing and Assembly of the Genome of Micropoecilia picta, a Fish with a Highly Degenerated Y Chromosome.Genome biology and evolution · 2021Article
- The timing of genetic degeneration of sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- How did the guppy Y chromosome evolve?PLoS genetics · 2021Article
- Natural family-free genomic distance.Algorithms for molecular biology : AMB · 2021Article
- Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species.G3 (Bethesda, Md.) · 2021Article
- Beyond Drosophila: resolving the rapid radiation of schizophoran flies with phylotranscriptomics.BMC biology · 2021Article
- Establishment and evolution of heterochromatin.Annals of the New York Academy of Sciences · 2020Review
- The Y Chromosome as a Battleground for Intragenomic Conflict.Trends in genetics : TIG · 2020Review
- Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group.Genome biology and evolution · 2020Article
- Patterns of Genomic Differentiation in the Drosophila nasuta Species Complex.Molecular biology and evolution · 2020Article
- Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling.Genes & development · 2019Article
- Ancestral male recombination in Drosophila albomicans produced geographically restricted neo-Y chromosome haplotypes varying in age and onset of decay.PLoS genetics · 2019Article
- The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes.Molecular biology and evolution · 2019Article
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2 authors at 1 institution in 1 country.
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Abstract
Sex chromosomes evolve distinctive types of chromatin from a pair of ancestral autosomes that are usually euchromatic. In Drosophila, the dosage-compensated X becomes enriched for hyperactive chromatin in males (mediated by H4K16ac), while the Y chromosome acquires silencing heterochromatin (enriched for H3K9me2/3). Drosophila autosomes are typically mostly euchromatic but the small dot chromosome has evolved a heterochromatin-like milieu (enriched for H3K9me2/3) that permits the normal expression of dot-linked genes, but which is different from typical pericentric heterochromatin. In Drosophila busckii, the dot chromosomes have fused to the ancestral sex chromosomes, creating a pair of 'neo-sex' chromosomes. Here we collect genomic, transcriptomic and epigenomic data from D. busckii, to investigate the evolutionary trajectory of sex chromosomes from a largely heterochromatic ancestor. We show that the neo-sex chromosomes formed <1 million years ago, but nearly 60% of neo-Y linked genes have already become non-functional. Expression levels are generally lower for the neo-Y alleles relative to their neo-X homologs, and the silencing heterochromatin mark H3K9me2, but not H3K9me3, is significantly enriched on silenced neo-Y genes. Despite rampant neo-Y degeneration, we find that the neo-X is deficient for the canonical histone modification mark of dosage compensation (H4K16ac), relative to autosomes or the compensated ancestral X chromosome, possibly reflecting constraints imposed on evolving hyperactive chromatin in an originally heterochromatic environment. Yet, neo-X genes are transcriptionally more active in males, relative to females, suggesting the evolution of incipient dosage compensation on the neo-X. Our data show that Y degeneration proceeds quickly after sex chromosomes become established through genomic and epigenetic changes, and are consistent with the idea that the evolution of sex-linked chromatin is influenced by its ancestral configuration.
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