ArticleChemical research in toxicology2015
Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans.
Article in Chemical research in toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- A New UPLC-qTOF Approach for Elucidating Furan and 2-Methylfuran Metabolites in Human Urine Samples after Coffee Consumption.Molecules (Basel, Switzerland) · 2020Trial
- Analytical Identification of Novel Furan Metabolites in Human Hepatocytes and Urine: Implications for Liver and Respiratory Disease Research.Chemical research in toxicology · 2026Article
- Glycerolphosphorylethanolamine and Several Other Biochemical Amines Are Targets of Furan's Reactive Metabolite in Rodents.Chemical research in toxicology · 2026Article
- Biomarker-based approach to human exposure assessment of furan in food.Archives of toxicology · 2025Article
- Stable Isotope Dilution Analysis (SIDA) to Determine Metabolites of Furan and 2-Methylfuran in Human Urine Samples: A Pilot Study.Metabolites · 2023Article
- Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis.Chemical research in toxicology · 2023Article
- The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment.Archives of toxicology · 2022Review
- A review of tobacco abuse and its epidemiological consequences.Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2022Review
- Urinary metabolites of furan in waterpipe tobacco smokers compared to non-smokers in home settings in the US.Toxicology letters · 2020Article
- Inhaled Furan Selectively Damages Club Cells in Lungs of A/J Mice.Toxicologic pathology · 2019Article
- Exposure assessment of process-related contaminants in food by biomarker monitoring.Archives of toxicology · 2018Review
- Risks for public health related to the presence of furan and methylfurans in food.EFSA journal. European Food Safety Authority · 2017Article
- Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.Chemico-biological interactions · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Furan, a possible human carcinogen, is found in heat treated foods and tobacco smoke. Previous studies have shown that humans are capable of converting furan to its reactive metabolite, cis-2-butene-1,4-dial (BDA), and therefore may be susceptible to furan toxicity. Human risk assessment of furan exposure has been stymied because of the lack of mechanism-based exposure biomarkers. Therefore, a sensitive LC-MS/MS assay for six furan metabolites was applied to measure their levels in urine from furan-exposed rodents as well as in human urine from smokers and nonsmokers. The metabolites that result from direct reaction of BDA with lysine (BDA-N(α)-acetyllysine) and from cysteine-BDA-lysine cross-links (N-acetylcysteine-BDA-lysine, N-acetylcysteine-BDA-N(α)-acetyllysine, and their sulfoxides) were targeted in this study. Five of the six metabolites were identified in urine from rodents treated with furan by gavage. BDA-N(α)-acetyllysine, N-acetylcysteine-BDA-lysine, and its sulfoxide were detected in most human urine samples from three different groups. The levels of N-acetylcysteine-BDA-lysine sulfoxide were more than 10 times higher than that of the corresponding sulfide in many samples. The amount of this metabolite was higher in smokers relative to that in nonsmokers and was significantly reduced following smoking cessation. Our results indicate a strong relationship between BDA-derived metabolites and smoking. Future studies will determine if levels of these biomarkers are associated with adverse health effects in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.