ArticleAmerican journal of respiratory and critical care medicine2015
Phenotype of normal spirometry in an aging population.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Trial
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- COPD Risk Phenotypes in Older Smokers: Evaluation in GLI- and GOLD-Defined Respiratory Impairment.Lung · 2024Article
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- 500 Meters Is a Result of 6-Minute Walk Test Which Differentiates Patients with High and Low Risk of Postoperative Complications after Lobectomy-A Validation Study.Journal of clinical medicine · 2021Article
- Value of metalloproteinases in predicting COPD in heavy urban smokers.Respiratory research · 2020Observational
- GPs should not try to detect mild COPD.NPJ primary care respiratory medicine · 2020Article
- FEVRespiratory care · 2020Article
- Impacts of Different Spirometry Reference Equations and Diagnostic Criteria on the Frequency of Airway Obstruction in Adult People of North China.International journal of chronic obstructive pulmonary disease · 2020Article
- Association of Breathing Reserve at Peak Exercise With Body Composition and Physical Function in Older Adults With Obesity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Physiologic Insights from the COPD Genetic Epidemiology Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Review
- Re-evaluation of combination therapy in chronic obstructive pulmonary disease (COPD).Respiratory medicine · 2019Article
- Joint Indian Chest Society-National College of Chest Physicians (India) guidelines for spirometry.Lung India : official organ of Indian Chest Society · 2019Article
- Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.Respiratory research · 2018Article
- Spirometric impairments, cardiovascular outcomes, and noncardiovascular death in older persons.Respiratory medicine · 2018Article
- Article
- Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.PloS one · 2018Article
- Spirometry, Static Lung Volumes, and Diffusing Capacity.Respiratory care · 2017Article
- The Global Lung Function Initiative (GLI) Network: bringing the world's respiratory reference values together.Breathe (Sheffield, England) · 2017Review
- The View of the Turkish Thoracic Society on the Report of the GOLD 2017 Global Strategy for the Diagnosis, Management, and Prevention of COPD.Turkish thoracic journal · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
rationaleIn aging populations, the commonly used Global Initiative for Chronic Obstructive Lung Disease (GOLD) may misclassify normal spirometry as respiratory impairment (airflow obstruction and restrictive pattern), including the presumption of respiratory disease (chronic obstructive pulmonary disease [COPD]).
objectivesTo evaluate the phenotype of normal spirometry as defined by a new approach from the Global Lung Initiative (GLI), overall and across GOLD spirometric categories.
methodsUsing data from COPDGene (n = 10,131; ages 45-81; smoking history, ≥10 pack-years), we evaluated spirometry and multiple phenotypes, including dyspnea severity (Modified Medical Research Council grade 0-4), health-related quality of life (St. George's Respiratory Questionnaire total score), 6-minute-walk distance, bronchodilator reversibility (FEV1 % change), computed tomography-measured percentage of lung with emphysema (% emphysema) and gas trapping (% gas trapping), and small airway dimensions (square root of the wall area for a standardized airway with an internal perimeter of 10 mm). MEASUREMENTS AND MAIN
resultsAmong 5,100 participants with GLI-defined normal spirometry, GOLD identified respiratory impairment in 1,146 (22.5%), including a restrictive pattern in 464 (9.1%), mild COPD in 380 (7.5%), moderate COPD in 302 (5.9%), and severe COPD in none. Overall, the phenotype of GLI-defined normal spirometry included normal adjusted mean values for dyspnea grade (0.8), St. George's Respiratory Questionnaire (15.9), 6-minute-walk distance (1,424 ft [434 m]), bronchodilator reversibility (2.7%), % emphysema (0.9%), % gas trapping (10.7%), and square root of the wall area for a standardized airway with an internal perimeter of 10 mm (3.65 mm); corresponding 95% confidence intervals were similarly normal. These phenotypes remained normal for GLI-defined normal spirometry across GOLD spirometric categories.
conclusionsGLI-defined normal spirometry, even when classified as respiratory impairment by GOLD, included adjusted mean values in the normal range for multiple phenotypes. These results suggest that among adults with GLI-defined normal spirometry, GOLD may misclassify normal phenotypes as having respiratory impairment.
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