Trial reportPloS one2015
Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Periodontitis as an independent risk factor for cardiovascular disease: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Association between Dental and Cardiovascular Diseases: A Systematic Review.Reviews in cardiovascular medicine · 2023Pooled it
- Periodontal disease and subsequent risk of cardiovascular outcome and all-cause mortality: A meta-analysis of prospective studies.PloS one · 2023Pooled it
- Major adverse cardiovascular event definitions used in observational analysis of administrative databases: a systematic review.BMC medical research methodology · 2021Pooled it
- Risk of incident cardiovascular disease in people with periodontal disease: A systematic review and meta-analysis.Clinical and experimental dental research · 2021Pooled it
- The association between periodontal disease and the risk of myocardial infarction: a pooled analysis of observational studies.BMC cardiovascular disorders · 2017Pooled it
- Periodontal Disease and Risk of Heart Failure: A Systematic Review and Meta-Analysis.International journal of dentistry · 2026Article
- More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024Review
- Crosstalk between periodontitis and cardiovascular risk.Frontiers in immunology · 2024Review
- Association between periodontitis stages and self-reported diseases in a Norwegian population: the HUNT study.BMC oral health · 2023Article
- Periodontal Diseases and Heart Diseases: A Systemic Review.Journal of pharmacy & bioallied sciences · 2023Article
- Unique inverse association between allergic rhinitis and periodontitis: a nationwide population-based study.Scientific reports · 2023Article
- Role of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in activation of inflammation in human umbilical vein endothelial cells stimulated byJournal of dental sciences · 2023Article
- Cardiovascular Diseases and Periodontitis.Advances in experimental medicine and biology · 2022Review
- Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases.Journal of clinical medicine · 2021Article
- Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease.International journal of molecular sciences · 2019Review
- Clinical outcomes in hypertensive patients treated with a single-pill fixed-dose combination of renin-angiotensin system inhibitor and thiazide diuretic.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health.Pteridines · 2018Article
- The Application and Future of Big Database Studies in Cardiology: A Single-Center Experience.Acta Cardiologica Sinica · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.
methodsFrom the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
resultsA total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.
conclusionsSevere form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.
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