ArticleBiomedical optics express2015
Photothermal optical lock-in optical coherence tomography for in vivo imaging.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.Scientific reports · 2024Article
- An OCT-A Analysis of the Importance of Intermediate Capillary Plexus in Diabetic Retinopathy: A Brief Review.Journal of clinical medicine · 2024Review
- Photothermal optical coherence tomography for 3D live cell detection and mapping.Optics continuum · 2023Article
- Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens.Scientific reports · 2023Article
- Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries.Biomedical optics express · 2022Article
- Transient-mode photothermal optical coherence tomography.Optics letters · 2021Article
- Investigation of GdJournal of fluorescence · 2021Article
- Coherently broadened, high-repetition-rate laser for stimulated Raman scattering-spectroscopic optical coherence tomography.Optics letters · 2019Article
- Photothermal optical coherence tomography of indocyanine green in ex vivo eyes.Optics letters · 2018Article
- Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.Translational vision science & technology · 2018Article
- In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.Scientific reports · 2017Article
- Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation.International journal of molecular sciences · 2017Review
- Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography.Biomedical optics express · 2016Article
- Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging.Scientific reports · 2016Article
- Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Photothermal OCT (PTOCT) provides high sensitivity to molecular targets in tissue, and occupies a spatial imaging regime that is attractive for small animal imaging. However, current implementations of PTOCT require extensive temporal sampling, resulting in slow frame rates and a large data burden that limit its in vivo utility. To address these limitations, we have implemented optical lock-in techniques for photothermal optical lock-in OCT (poli-OCT), and demonstrated the in vivo imaging capabilities of this approach. The poli-OCT signal was assessed in tissue-mimicking phantoms containing indocyanine green (ICG), an FDA approved small molecule that has not been previously imaged in vivo with PTOCT. Then, the effects of in vivo blood flow and motion artifact were assessed and attenuated, and in vivo poli-OCT was demonstrated with both ICG and gold nanorods as contrast agents. Experiments revealed that poli-OCT signals agreed with optical lock-in theory and the bio-heat equation, and the system exhibited shot noise limited performance. In phantoms containing biologically relevant concentrations of ICG (1 µg/ml), the poli-OCT signal was significantly greater than control phantoms (p<0.05), demonstrating sensitivity to small molecules. Finally, in vivo poli-OCT of ICG identified the lymphatic vessels in a mouse ear, and also identified low concentrations (200 pM) of gold nanorods in subcutaneous injections at frame rates ten times faster than previously reported. This work illustrates that future in vivo molecular imaging studies could benefit from the improved acquisition and analysis times enabled by poli-OCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.