Evidence map›Paper›PMID 26114040›Full record

ArticleBiomedical optics express2015

Optimizing light transport in scintillation crystals for time-of-flight PET: an experimental and optical Monte Carlo simulation study.

Eric Berg, Emilie Roncali, Simon R Cherry

Abstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric BergDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA ; These authors contributed equally.
Emilie RoncaliDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA ; These authors contributed equally.
Simon R CherryDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Enabling technologies for ultra-high sensitivity PET scanners (PQ13)R01CA170874 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADAWI, RAMSEY D. · 2012 to 2014
$1.5M
NCI NIH HHS R01 CA170874NIH HHS P51 OD011107
6 · The paper itself

Abstract

Achieving excellent timing resolution in gamma ray detectors is crucial in several applications such as medical imaging with time-of-flight positron emission tomography (TOF-PET). Although many factors impact the overall system timing resolution, the statistical nature of scintillation light, including photon production and transport in the crystal to the photodetector, is typically the limiting factor for modern scintillation detectors. In this study, we investigated the impact of surface treatment, in particular, roughening select areas of otherwise polished crystals, on light transport and timing resolution. A custom Monte Carlo photon tracking tool was used to gain insight into changes in light collection and timing resolution that were observed experimentally: select roughening configurations increased the light collection up to 25% and improved timing resolution by 15% compared to crystals with all polished surfaces. Simulations showed that partial surface roughening caused a greater number of photons to be reflected towards the photodetector and increased the initial rate of photoelectron production. This study provides a simple method to improve timing resolution and light collection in scintillator-based gamma ray detectors, a topic of high importance in the field of TOF-PET. Additionally, we demonstrated utility of our Monte Carlo simulation tool to accurately predict the effect of altering crystal surfaces on light collection and timing resolution.

Indexed as

(120.3890) Medical optics instrumentation(170.2670) Gamma ray imaging(170.5280) Photon migration(240.0240) Optics at surfaces(240.5770) Roughness(260.1180) Crystal optics

Identifiers

PMID26114040
PMCPMC4473755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.