ArticleBiomedical optics express2015
Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Optical coherence tomography for noninvasive monitoring of drug delivery.Advanced drug delivery reviews · 2025Review
- Raman difference spectroscopy and U-Net convolutional neural network for molecular analysis of cutaneous neurofibroma.PloS one · 2024Article
- Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.Journal of biophotonics · 2023Review
- Optical coherence tomography evaluation of vaginal epithelial thickness during COJournal of biophotonics · 2022Article
- Optical coherence tomography-guided confocal Raman microspectroscopy for rapid measurements in tissues.Biomedical optics express · 2022Article
- Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications.Journal of biomedical optics · 2021Review
- HIV Pathogenesis in the Human Female Reproductive Tract.Current HIV/AIDS reports · 2021Review
- Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy.Biomedical optics express · 2021Article
- Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model.PloS one · 2021Article
- Tissue Phantoms for Biomedical Applications in Raman Spectroscopy: A Review.Biomedical engineering and computational biology · 2020Review
- Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations forNeurophotonics · 2019Article
- Epithelial Cells and Fibroblasts from the Human Female Reproductive Tract Accumulate and Release TFV and TAF to Sustain Inhibition of HIV Infection of CD4+ T cells.Scientific reports · 2019Article
- Rapid label-free analysis of Opisthorchis viverrini eggs in fecal specimens using confocal Raman spectroscopy.PloS one · 2019Article
- Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography.Drug delivery and translational research · 2018Article
- Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.Journal of biophotonics · 2017Article
- Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities.AIDS research and human retroviruses · 2017Review
- Label-Free Measurements of Tenofovir Diffusion Coefficients in a Microbicide Gel Using Raman Spectroscopy.Journal of pharmaceutical sciences · 2017Article
- Article
- Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.