ArticleMedical gas research2015
Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model.
Article in Medical gas research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders.Medical gas research · 2025Review
- Xenon Antiaggregant Effects.Bulletin of experimental biology and medicine · 2024Article
- Effects of inhaled low-concentration xenon gas on naltrexone-precipitated withdrawal symptoms in morphine-dependent mice.Drug and alcohol dependence · 2024Article
- Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.Pediatric research · 2021Review
- Ventilation With Argon Improves Survival With Good Neurological Recovery After Prolonged Untreated Cardiac Arrest in Pigs.Journal of the American Heart Association · 2020Article
- Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats.Journal of translational medicine · 2019Article
- Article
- Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- New Beginnings forMedical gas research · 2016Article
- Hydrogen therapy: from mechanism to cerebral diseases.Medical gas research · 2016Review
- Gas transport duringMedical gas research · 2016Article
- What's new inMedical gas researchArticle
- The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease.Medical gas researchArticle
- For the pursuit of oxygen and carbon dioxide channels in mitochondria.Medical gas researchArticle
- Argon pharmacokinetics: a solubility measurement technique.Medical gas researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew gas therapies using inert gases such as xenon and argon are being studied, which would require chronically administered repeating doses. The pharmacokinetics of this type of administration has not been addressed in the literature.
methodsA physiologically based pharmacokinetics (PBPK) model for humans, pigs, mice, and rats has been developed to investigate the unique aspects of the chronic administration of inert gas therapies. The absorption, distribution, metabolism and excretion (ADME) models are as follows: absorption in all compartments is assumed to be perfusion limited, no metabolism of the gases occurs, and excretion is only the reverse process of absorption through the lungs and exhaled.
resultsThe model has shown that there can be a residual dose, equivalent to constant administration, for chronic repeated dosing of xenon in humans. However, this is not necessarily the case for small animals used in pre-clinical studies.
conclusionsThe use of standard pharmacokinetics parameters such as area under the curve would be more appropriate to assess the delivered dose of chronic gas administration than the gas concentration in the delivery system that is typically reported in the scientific literature because species and gas differences can result in very different delivered doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.