Evidence map›Paper›PMID 26113865›Full record

ReviewStem cells international2015

Making Blood: The Haematopoietic Niche throughout Ontogeny.

Mohammad A Al-Drees, Jia Hao Yeo, Badwi B Boumelhem, Veronica I Antas, Kurt W L Brigden, Chanukya K Colonne, Stuart T Fraser

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Biomechanical cues as master regulators of hematopoietic stem cell fate.Cellular and molecular life sciences : CMLS · 2021
    Review
  3. Hematopoietic stem cell stretches and moves in its bone marrow niche.Critical reviews in oncology/hematology · 2021
    Review
  4. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  5. Erythroid Lineage Cells in the Liver: Novel Immune Regulators and Beyond.Journal of clinical and translational hepatology · 2020
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Lung as a Niche for Hematopoietic Progenitors.Stem cell reviews and reports · 2017
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad A Al-DreesDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia ; Laboratory of Bone Marrow and Stem Cell Processing, Department of Medical Oncology, Medical Oncology and Stem Cell Transplant Center, Al-Sabah Medical Area, Kuwait.
Jia Hao YeoDiscipline of Anatomy & Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.
Badwi B BoumelhemDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.
Veronica I AntasDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.
Kurt W L BrigdenDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.
Chanukya K ColonneDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.
Stuart T FraserDiscipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia ; Discipline of Anatomy & Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately one-quarter of all cells in the adult human body are blood cells. The haematopoietic system is therefore massive in scale and requires exquisite regulation to be maintained under homeostatic conditions. It must also be able to respond when needed, such as during infection or following blood loss, to produce more blood cells. Supporting cells serve to maintain haematopoietic stem and progenitor cells during homeostatic and pathological conditions. This coalition of supportive cell types, organised in specific tissues, is termed the haematopoietic niche. Haematopoietic stem and progenitor cells are generated in a number of distinct locations during mammalian embryogenesis. These stem and progenitor cells migrate to a variety of anatomical locations through the conceptus until finally homing to the bone marrow shortly before birth. Under stress, extramedullary haematopoiesis can take place in regions that are typically lacking in blood-producing activity. Our aim in this review is to examine blood production throughout the embryo and adult, under normal and pathological conditions, to identify commonalities and distinctions between each niche. A clearer understanding of the mechanism underlying each haematopoietic niche can be applied to improving ex vivo cultures of haematopoietic stem cells and potentially lead to new directions for transplantation medicine.

Identifiers

PMID26113865
PMCPMC4465740

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.