ReviewFrontiers in physiology2015
A new paradigm for muscle contraction.
Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 112 citations in OpenAlex.
- Temperature changes reveal different transcriptional responses in the larvae of the bark beetle Dendroctonus rhizophagus during the cold season.Scientific reports · 2026Article
- Neuromechanical basis of region-specific differences and their implications for sport performance and injury prevention: a narrative review.European journal of applied physiology · 2025Review
- Physiological, perceived, and physical demands of recreational 3 × 3 basketball and high-intensity interval training in sedentary adult women.Biology of sport · 2025Article
- Pressure Between Residual Limb and Transtibial Prosthesis Socket Considering Muscle Contraction: A Finite Element Study.Annals of biomedical engineering · 2025Article
- The association between daily movement behavior and adjusted handgrip strength in post-menopausal women.Frontiers in nutrition · 2025Article
- Four-compartment muscle fatigue model to predict metabolic inhibition and long-lasting nonmetabolic components.Frontiers in physiology · 2024Article
- Individual Muscle Force Estimation in the Human Forearm Using Multi-Muscle MR Elastography (MM-MRE).IEEE transactions on bio-medical engineering · 2023Article
- Relationship between Physical Activity and Sedentary Behavior, Spinal Curvatures, Endurance and Balance of the Trunk Muscles-Extended Physical Health Analysis in Young Adults.International journal of environmental research and public health · 2023Article
- Biceps Brachii and Brachioradialis Excitation in Biceps Curl Exercise: Different Handgrips, Different Synergy.Sports (Basel, Switzerland) · 2023Article
- Article
- Bilateral Biceps Curl Shows Distinct Biceps Brachii and Anterior Deltoid Excitation Comparing Straight vs. EZ Barbell Coupled with Arms Flexion/No-Flexion.Journal of functional morphology and kinesiology · 2023Article
- Sedentary lifestyle of university students is detrimental to the thoracic spine in men and to the lumbar spine in women.PloS one · 2023Article
- Electrical impedance myography combined with quantitative assessment techniques in paretic muscle of stroke survivors: Insights and challenges.Frontiers in aging neuroscience · 2023Article
- Role of Muscle LIM Protein in Mechanotransduction Process.International journal of molecular sciences · 2022Review
- Increased Stiffness of the Superficial Cervical Extensor Muscles in Patients With Cervicogenic Headache: A Study Using Shear Wave Elastography.Frontiers in neurology · 2022Article
- What Can We Learn from Single Sarcomere and Myofibril Preparations?Frontiers in physiology · 2022Review
- Effect of Active Lengthening and Shortening on Small-Angle X-ray Reflections in Skinned Skeletal Muscle Fibres.International journal of molecular sciences · 2021Article
- Effects of Hip Flexion on Knee Extension and Flexion Isokinetic Angle-Specific Torques and HQ-Ratios.Sports medicine - open · 2021Article
- The association of reactive balance control and spinal curvature under lumbar muscle fatigue.PeerJ · 2021Article
- History-dependence of muscle slack length in humans: effects of contraction intensity, stretch amplitude, and time.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the past 60 years, muscle contraction had been thought to be governed exclusively by the contractile filaments, actin, and myosin. This thinking explained most observations for concentric and isometric, but not for eccentric muscle contractions. Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin. Titin was found to bind calcium upon activation, thereby increasing its structural stability, and thus its stiffness and force. Furthermore, there is increasing evidence that the proximal part of titin binds to actin in an activation- and force-dependent manner, thereby shortening its free length, thus increasing its stiffness and force. Therefore, we propose that muscle contraction involves three filaments, actin, myosin and titin, and that titin regulates force by binding calcium and by shortening its spring length by binding to actin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.