ArticleThe Australian and New Zealand journal of psychiatry2016
Cell proliferation is reduced in the hippocampus in schizophrenia.
Article in The Australian and New Zealand journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies.Molecular psychiatry · 2021Pooled it
- A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese.Translational psychiatry · 2016Pooled it
- Tanshinone IIA Promotes Hippocampal Neurogenesis in ApoEMolecular neurobiology · 2025Article
- Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis.World journal of psychiatry · 2025Article
- Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors.Cell stem cell · 2025Article
- Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role ofWorld journal of stem cells · 2025Review
- Human adult hippocampal neurogenesis in health and disease.Aging brain · 2025Article
- Article
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a.Nature communications · 2024Article
- Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients.Translational psychiatry · 2023Article
- Consistency and Variation in Doublecortin and Ki67 Antigen Detection in the Brain Tissue of Different Mammals, including Humans.International journal of molecular sciences · 2023Article
- Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation.Journal of neuroinflammation · 2022Article
- Effects of exosomes on adult hippocampal neurogenesis and neuropsychiatric disorders.Molecular biology reports · 2022Review
- A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity.Molecular psychiatry · 2022Article
- Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids.Molecular psychiatry · 2022Article
- Reduced adult neurogenesis is associated with increased macrophages in the subependymal zone in schizophrenia.Molecular psychiatry · 2021Article
- Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.Molecular psychiatry · 2021Article
- Environmental enrichment rescues survival and function of adult-born neurons following early life stress.Molecular psychiatry · 2021Article
- Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms.Translational psychiatry · 2021Article
Corrections and comments
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3 authors.
Funding
Abstract
objectiveThe molecular and cellular basis of structural and functional abnormalities of the hippocampus found in schizophrenia is currently unclear. Postnatal neurogenesis contributes to hippocampal function in animal models and is correlated with hippocampal volume in primates. Reduced hippocampal cell proliferation has been previously reported in schizophrenia, which may contribute to hippocampal dysfunction.
methodWe measured the cell proliferation marker, Ki67, in post-mortem hippocampal tissue from patients with schizophrenia (n = 10) and matched controls (n = 16). Ki67-labelled cells were counted within the dentate gyrus and hilus on sections taken from the anterior hippocampus.
resultsWe replicated the finding of a significant reduction in Ki67+ cells/mm² in schizophrenia cases compared to controls (t24 = 2.1, p = 0.023). In our relatively small sample, we did not find a relationship between Ki67+ cells and age overall, or between Ki67 + cells and duration of illness or antipsychotic treatment in people with schizophrenia.
conclusionOur results confirm that reduced hippocampal cell proliferation may be present in schizophrenia. Restoring hippocampal neurogenesis may be a potential therapeutic target for the treatment of hippocampal dysfunction in schizophrenia.
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