ArticleInternational health2016
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia.
Article in International health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Associations between podoconiosis and pedogenic factors globally - A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Prevalence, assessment and correlates of mental health problems in neglected tropical diseases: a systematic review.International health · 2024Pooled it
- The impact of podoconiosis, lymphatic filariasis, and leprosy on disability and mental well-being: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Mapping the global distribution of podoconiosis: Applying an evidence consensus approach.PLoS neglected tropical diseases · 2019Pooled it
- Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs.Parasites & vectors · 2018Pooled it
- Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis in northern Ethiopia (GoLBeT): a pragmatic randomised controlled trial.The Lancet. Global health · 2018Trial
- Article
- Contextual aspects of implementing an intervention to mitigate podoconiosis-related stigma in Musanze district, Rwanda.International journal for equity in health · 2026Article
- Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: A population-based cross-sectional study (the MorLo project).PLoS neglected tropical diseases · 2025Article
- Lower limb lymphoedema-related mental depression: A systematic review and meta-analysis of non-cancer-related studies.Global epidemiology · 2025Review
- Uncovering intersecting stigmas experienced by people affected by podoconiosis in Nyamasheke district, Rwanda.PLoS neglected tropical diseases · 2024Article
- 'The Lost Peace': Evidencing the Syndemic Relationship between Neglected Tropical Diseases and Mental Distress in Liberia.Tropical medicine and infectious disease · 2024Article
- Bearing the burden: Podoconiosis and mental health-A three-way comparative cross-sectional study in Rwanda.PLoS neglected tropical diseases · 2024Article
- The relationship of kinesiophobia in patients with lymphedema: a case-control investigation.Frontiers in psychiatry · 2024Article
- Mental health conditions in people affected by filarial lymphoedema in Malawi: prevalence, associated risk factors and the impact of an enhanced self-care intervention.International health · 2023Article
- Stigma, depression and quality of life among people affected by neglected tropical diseases in Nepal.International health · 2023Article
- Geostatistical modelling of the distribution, risk and burden of podoconiosis in Kenya.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Depressive symptoms and their severity in a sample with lymphedema: a case-control investigation.Frontiers in psychiatry · 2023Article
- Health-related quality of life and associated factors among adult podoconiosis patients in Debre Elias district Northwest, Ethiopia.PLoS neglected tropical diseases · 2022Article
- A qualitative process evaluation of a community conversation intervention to reduce stigma related to lower limb lymphoedema in Northern Ethiopia.BMC health services research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about depressive symptoms in podoconiosis despite the independent contribution of depression to worse health outcomes and disability in people with other chronic disorders.
methodTwo-hundred and seventy-one individuals with podoconiosis and 268 healthy neighbours (individuals from the nearest household in any direction) were investigated for depressive symptoms using a validated Amharic version of the Patient Health Questionnaire (PHQ-9). The WHO Disability Assessment Schedule II (WHODAS II) tool was used to measure disability. Logistic regression and zero inflated negative binomial regression were used to identify factors associated with elevated depressive symptoms, and disability, respectively.
resultsAmong study participants with podoconiosis, 12.6% (34/269) had high levels of depressive symptoms (scoring 5 or more points on the PHQ-9, on two assessments two weeks apart) compared to 0.7% (2/268) of healthy neighbours (p<0.001). Having podoconiosis and being older were significantly associated with increased odds of a high PHQ-9 score (adjusted odds ratios [AOR] 11.42; 95% CI: 2.44-53.44 and AOR 1.04; 95% CI: 1.00-1.08, respectively). Significant predictors of a higher disability score were having podoconiosis (WHODAS II multiplier value: 1.48; 95% CI: 1.39-1.58) and having a high PHQ-9 score (1.07; 95% CI: 1.06-1.08).
conclusionWe recommend integrating evidence-based treatments for depression into podoconiosis interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.