ArticleSchizophrenia bulletin2016
Hippocampal Shape Abnormalities Predict Symptom Progression in Neuroleptic-Free Youth at Ultrahigh Risk for Psychosis.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- A Supervised Exercise Intervention for Youth at Risk for Psychosis: An Open-Label Pilot Study.The Journal of clinical psychiatryTrial
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence.Psychoneuroendocrinology · 2024Article
- Motor precision deficits in clinical high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2024Article
- The impact of menarche on hippocampal mechanisms of severity of psychotic-like experiences in the ABCD study.Psychoneuroendocrinology · 2024Article
- Multipronged investigation of morphometry and connectivity of hippocampal network in relation to risk for psychosis using ultrahigh field MRI.Schizophrenia research · 2023Article
- Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment.Brain sciences · 2023Article
- Hippocampal subfields, daily stressors, and resting cortisol in individuals at clinical high-risk for psychosis.Psychoneuroendocrinology · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- The relationship between stress responding in family context and stress sensitivity with sleep dysfunction in individuals at clinical high-risk for psychosis.Journal of psychiatric research · 2022Article
- Cerebellar correlates of social dysfunction among individuals at clinical high risk for psychosis.Frontiers in psychiatry · 2022Article
- History of trauma is a critical treatment target for individuals at clinical high-risk for psychosis.Frontiers in psychiatry · 2022Article
- Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.Development and psychopathology · 2021Article
- Neuroimaging Markers of Resiliency in Youth at Clinical High Risk for Psychosis: A Qualitative Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Reduced Hippocampal Subfield Volume in Schizophrenia and Clinical High-Risk State for Psychosis.Frontiers in psychiatry · 2021Article
- Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants.Social cognitive and affective neuroscience · 2020Article
- Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.Molecular psychiatry · 2020Article
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
introductionHippocampal abnormalities have been widely studied in schizophrenia spectrum populations including those at ultrahigh risk (UHR) for psychosis. There have been inconsistent findings concerning hippocampal morphology prior to and during the transition to psychosis, and little is known about how specific subregions are related to the symptom progression.
methodsA total of 80 participants (38 UHR and 42 healthy controls) underwent a 3T MRI scan, as well as structured clinical interviews. Shape analysis of hippocampi was conducted with FSL/FIRST vertex analysis to yield a localized measure of shape differences between groups. A subgroup of the sample (24 UHR and 24 controls) also returned for a 12-month clinical follow-up assessment.
resultsThe UHR group exhibited smaller hippocampal volumes bilaterally, and shape analysis revealed significant inversion in the left ventral posterior hippocampus in the UHR group. Greater inversion in this subregion was related to elevated symptomatology at baseline and increased positive symptoms, negative symptoms, and impaired tolerance to normal stress 12 months later. These results did not hold when left hippocampal volume was used as a predictor instead. DISCUSSION: This represents the first study to use vertex analysis in a UHR sample and results suggest that abnormalities in hippocampal shape appear to reflect underlying pathogenic processes driving the progression of illness. These findings suggest that examining shape and volume may provide an important new perspective for our conception of brain alterations in the UHR period.
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