ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2015
Simulation studies of circular muscle contraction, longitudinal muscle shortening, and their coordination in esophageal transport.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Integrin-Alpha-6+ Cells Are Responsible for Blastema Formation During Oral Siphon Regeneration in Ciona robusta.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats.The journal of physiological sciences : JPS · 2024Article
- A mechanics-based perspective on the function of the esophagogastric junction during functional luminal imaging probe manometry.Biomechanics and modeling in mechanobiology · 2023Article
- Peristaltic regimes in esophageal transport.Biomechanics and modeling in mechanobiology · 2023Article
- Normative values of intra-bolus pressure and esophageal compliance based on 4D high-resolution impedance manometry.Neurogastroenterology and motility · 2022Article
- Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm.Therapeutic advances in gastroenterology · 2020Article
- Immersed Methods for Fluid-Structure Interaction.Annual review of fluid mechanics · 2020Article
- Hybrid finite difference/finite element immersed boundary method.International journal for numerical methods in biomedical engineering · 2017Article
- A continuum mechanics-based musculo-mechanical model for esophageal transport.Journal of computational physics · 2017Article
- Could the peristaltic transition zone be caused by non-uniform esophageal muscle fiber architecture? A simulation study.Neurogastroenterology and motility · 2017Article
- Simulation studies of the role of esophageal mucosa in bolus transport.Biomechanics and modeling in mechanobiology · 2017Article
- Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease.American journal of physiology. Gastrointestinal and liver physiology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
On the basis of a fully coupled active musculomechanical model for esophageal transport, we aimed to find the roles of circular muscle (CM) contraction and longitudinal muscle (LM) shortening in esophageal transport, and the influence of their coordination. Two groups of studies were conducted using a computational model. In the first group, bolus transport with only CM contraction, only LM shortening, or both was simulated. Overall features and detailed information on pressure and the cross-sectional area (CSA) of mucosal and the two muscle layers were analyzed. In the second group, bolus transport with varying delay in CM contraction or LM shortening was simulated. The effect of delay on esophageal transport was studied. For cases showing abnormal transport, pressure and CSA were further analyzed. CM contraction by itself was sufficient to transport bolus, but LM shortening by itself was not. CM contraction decreased the CSA and the radius of the muscle layer locally, but LM shortening increased the CSA. Synchronized CM contraction and LM shortening led to overlapping of muscle CSA and pressure peaks. Advancing LM shortening adversely influenced bolus transport, whereas lagging LM shortening was irrelevant to bolus transport. In conclusion, CM contraction generates high squeezing pressure, which plays a primary role in esophageal transport. LM shortening increases muscle CSA, which helps to strengthen CM contraction. Advancing LM shortening decreases esophageal distensibility in the bolus region. Lagging LM shortening no longer helps esophageal transport. Synchronized CM contraction and LM shortening seems to be most effective for esophageal transport.
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