Observational studyAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2015
Immediate Discharge and Home Treatment With Rivaroxaban of Low-risk Venous Thromboembolism Diagnosed in Two U.S. Emergency Departments: A One-year Preplanned Analysis.
Observational study in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outpatient Treatment of Low-Risk Venous Thromboembolism With Target Specific Anticoagulant
Randomized Trial to Test the Effect of Rivaroxaban or Apixaban on Menstrual Blood Loss in Women
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comprehensive Outpatient Management of Low-Risk Pulmonary Embolism: Can Primary Care Do This? A Narrative Review.The Permanente journal · 2020Pooled it
- Systematic Review of Real-World Studies Evaluating Characteristics Associated With or Programs Designed to Facilitate Outpatient Management of Deep Vein Thrombosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Pooled it
- Findings From 12-lead Electrocardiography That Predict Circulatory Shock From Pulmonary Embolism: Systematic Review and Meta-analysis.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2015Pooled it
- Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial.European heart journal · 2021Trial
- Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial.Circulation. Cardiovascular quality and outcomes · 2021Trial
- Emergency Department Discharge of Pulmonary Embolus Patients.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2018Trial
- Emerging strategies in venous thromboembolism: a narrative review of pharmacological innovations.Thrombosis journal · 2026Review
- Outpatient Management of Pulmonary Embolism Patients with Direct Oral Anticoagulants: A Systematic Review.Journal of clinical medicine · 2025Review
- Pulmonary embolism in United States emergency departments, 2010-2018.Scientific reports · 2023Article
- Can right ventricular assessments improve triaging of low risk pulmonary embolism?Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022Article
- Evaluating the Appropriateness of Pulmonary Embolism Admissions in a Community Hospital Emergency Department.Cureus · 2022Article
- Article
- Outpatient treatment of pulmonary embolism.Breathe (Sheffield, England) · 2020Review
- Listen to Your Heart (but DON'T Look at Theirs): Risk Assessment for Home Treatment of Pulmonary Embolism.American journal of respiratory and critical care medicine · 2020Article
- Reducing the hospital burden associated with the treatment of pulmonary embolism.Journal of thrombosis and haemostasis : JTH · 2019Review
- Highlights from the ERS International Congress 2018: Assembly 13 - Pulmonary Vascular Diseases.ERJ open research · 2019Article
- Systematic literature review of treatment patterns for venous thromboembolism patients during transitions from inpatient to post-discharge settings.ClinicoEconomics and outcomes research : CEOR · 2019Article
- Key topics in pulmonary vascular diseases (assembly 13) from the European Respiratory Society 2018 Parisian Congress.Journal of thoracic disease · 2018Article
- Implementation and Preliminary Clinical Outcomes of a Pharmacist-managed Venous Thromboembolism Clinic for Patients Treated With Rivaroxaban Post Emergency Department Discharge.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2018Article
- A one year audit of patients with venous thromboembolism presenting to a tertiary hospital in Johannesburg, South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study hypothesis was that a target-specific anticoagulant would allow successful home treatment of selected patients with deep vein thrombosis (DVT) and pulmonary embolism (PE) diagnosed in two urban emergency departments (EDs).
methodsA protocol was established for treating low-risk DVT or PE patients with rivaroxaban and clinic, follow-up at both 2 to 5 weeks, and 3 to 6 months. Patients were determined to be low-risk by using a modified version of the Hestia criteria, supplemented by additional criteria for patients with active cancer. Acceptable outcome rates were defined as venous thromboembolism (VTE) recurrence ≤ 2.1% or bleeding ≤ 9.4% during treatment. VTE recurrence required positive imaging of any VTE. The International Society of Thrombosis and Hemostasis definition of major or clinically relevant nonmajor bleeding was used.
resultsFrom March 2013 through April 2014, a total of 106 patients were treated. Seventy-one (68%) had DVT, 30 (28%) had PE, and five (3%) had both, representing 51% of all DVTs and 27% of all PEs diagnosed in both EDs during the period of study. The 106 patients have been followed for a mean (±SD) of 389 (±111) days (range = 213 to 594 days). No patient had VTE recurrence, and no patient had a major or clinically relevant bleeding event while on therapy (none of the 106, 0%, 95% confidence interval [CI] = 0% to 3.4%). However, three patients 2.8% (95% CI = 1% to 8%) had recurrent DVT after cessation of therapy.
conclusionsPatients diagnosed with VTE and immediately discharged from the ED while treated with rivaroxaban had a low rate of VTE recurrence and bleeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.