ReviewCurrent rheumatology reports2015
Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis.
Review in Current rheumatology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Trial
- Evaluating therapeutic efficacy of iopanoic acid in a DMM-induced osteoarthritis mouse model and osteochondral lesioned human explants.Osteoarthritis and cartilage open · 2026Article
- Identification and Validation of a Novel WNK2 Inhibitor: A New Genetically Informed Target for Osteoarthritis Drug Development.ACS omega · 2026Article
- Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society's Symposium on Targets for Osteoarthritis Research: Part 1: Epidemiology, Pathophysiology, and Current Imaging Approaches.Foot & ankle orthopaedics · 2022Review
- NOD/RIPK2 signalling pathway contributes to osteoarthritis susceptibility.Annals of the rheumatic diseases · 2022Article
- Familial Clustering and Genetic Analysis of Severe Thumb Carpometacarpal Joint Osteoarthritis in a Large Statewide Cohort.The Journal of hand surgery · 2022Article
- Familial Clustering of Erosive Hand Osteoarthritis in a Large Statewide Cohort.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.Human molecular genetics · 2018Article
- The association ofTherapeutics and clinical risk management · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collaborative work has led to the identification of robust osteoarthritis susceptibility genes. The translation of these gene deviations towards underlying biological mechanisms remains challenging yet necessary to allow the transition of these results in drug development and to applications in the clinic. Besides the availability of disease-relevant tissues which will contribute to a deeper insight into ongoing pathophysiological processes as result of the gene deviations, availability of respective cells will be key to establish in vitro models to further characterize genetic variants at a transcriptional and functional level. To allow exploration of effective use of drugs and biologicals such findings should eventually be further tested in in vivo models. In this review, we discuss possibilities for the implementation of an effective functional genomic pipeline for bench-to-bedside translation of identified susceptibility loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.