ArticleGenome biology and evolution2015
How Did Arthropod Sesquiterpenoids and Ecdysteroids Arise? Comparison of Hormonal Pathway Genes in Noninsect Arthropod Genomes.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 88 citations in OpenAlex.
- Fusion dsRNA targeting ecdysteroid signaling provides efficient and selective RNAi-based control of spider mites.Pest management science · 2026Article
- 20-Hydroxyecdysone primary response gene LmBlimp-1 controls locust molt and survival by regulating chitin metabolism.Pest management science · 2026Article
- Evolutionary dynamics of the arthropod molting machinery.Molecular biology and evolution · 2026Review
- Identification of ecdysteroids and ecdysteroidogenic genes in dragonflies and damselflies.Scientific reports · 2025Article
- Sesquiterpenoid Hormones Farnesoic Acid and Methyl Farnesoate Regulate Different Gene Sets in ShrimpBiomolecules · 2025Article
- The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy.The Journal of biological chemistry · 2025Article
- CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Biomolecules · 2024Review
- Article
- Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome.Molecular & cellular proteomics : MCP · 2023Article
- The genome of the deep-sea anemoneProceedings. Biological sciences · 2023Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- The genome and sex-dependent responses to temperature in the common yellow butterfly, Eurema hecabe.BMC biology · 2023Article
- Rethinking Sesquiterpenoids: A Widespread Hormone in Animals.International journal of molecular sciences · 2022Article
- Genome of the ramshorn snail Biomphalaria straminea-an obligate intermediate host of schistosomiasis.GigaScience · 2022Article
- The cytochrome P450 Cyp6t3 is not required for ecdysone biosynthesis inmicroPublication biology · 2022Article
- Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genomic insights into the sessile life and biofouling of barnacles (Crustacea: Cirripedia).Heliyon · 2021Article
- Juvenile hormone pathway in honey bee larvae: A source of possible signal molecules for the reproductive behavior ofEcology and evolution · 2021Article
- The Fate of Dietary Cholesterol in the Kissing BugFrontiers in physiology · 2021Article
- Genomic Characterization and Expression of Juvenile Hormone Esterase-Like Carboxylesterase Genes in Pacific White Shrimp,International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phylum Arthropoda contains the largest number of described living animal species, with insects and crustaceans dominating the terrestrial and aquatic environments, respectively. Their successful radiations have long been linked to their rigid exoskeleton in conjunction with their specialized endocrine systems. In order to understand how hormones can contribute to the evolution of these animals, here, we have categorized the sesquiterpenoid and ecdysteroid pathway genes in the noninsect arthropod genomes, which are known to play important roles in the regulation of molting and metamorphosis in insects. In our analyses, the majority of gene homologs involved in the biosynthetic, degradative, and signaling pathways of sesquiterpenoids and ecdysteroids can be identified, implying these two hormonal systems were present in the last common ancestor of arthropods. Moreover, we found that the "Broad-Complex" was specifically gained in the Pancrustacea, and the innovation of juvenile hormone (JH) in the insect linage correlates with the gain of the JH epoxidase (CYP15A1/C1) and the key residue changes in the binding domain of JH receptor ("Methoprene-tolerant"). Furthermore, the gain of "Phantom" differentiates chelicerates from the other arthropods in using ponasterone A rather than 20-hydroxyecdysone as molting hormone. This study establishes a comprehensive framework for interpreting the evolution of these vital hormonal pathways in these most successful animals, the arthropods, for the first time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.