Evidence map›Paper›PMID 26112898›Full record

ReviewClinical imaging

Imaging-based screening: maximizing benefits and minimizing harms.

Jessica C Germino, Joann G Elmore, Ruth C Carlos, Christoph I Lee

Abstract readReview
In one paragraph

Review in Clinical imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Surveillance for Late Effects in Childhood Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica C GerminoDepartment of Radiology, University of Washington School of Medicine, 825 Eastlake Avenue East, G3-200, Seattle, WA, 98109-1023. Electronic address: germinoj@uw.edu.
Joann G ElmoreDepartment of Medicine, University of Washington School of Medicine, 325 Ninth Avenue, Box 359780, Seattle, WA, 98104-2499; Department of Epidemiology, University of Washington School of Public Health, 325 Ninth Avenue, Box 359780, Seattle, WA, 98104-2499. Electronic address: jelmore@uw.edu.
Ruth C CarlosDepartment of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI, 48109; University of Michigan Institute for Healthcare Policy and Innovation, 1500 East Medical Center Drive, Ann Arbor, MI, 48109. Electronic address: rcarlos@med.umich.edu.
Christoph I LeeDepartment of Radiology, University of Washington School of Medicine, 825 Eastlake Avenue East, G3-200, Seattle, WA, 98109-1023; Department of Health Services, University of Washington School of Public Health, 825 Eastlake Avenue East, Seattle, WA, 98109; Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, 825 Eastlake Avenue East, Seattle, WA, 98109. Electronic address: stophlee@uw.edu.

Funding

Improving Accuracy &Outcomes of Breast Cancer ScreeningK05CA104699 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G · 2004 to 2014
$1.2M
NCI NIH HHS K05 CA 104699NCI NIH HHS K05 CA104699
6 · The paper itself

Abstract

Advanced imaging technologies play a central role in screening asymptomatic patients. However, the balance between imaging-based screening's potential benefits versus risks is sometimes unclear. Radiologists will have to address ongoing concerns, including high false-positive rates, incidental findings outside the organ of interest, overdiagnosis, and potential risks from radiation exposure. In this article, we provide a brief overview of these recurring controversies and suggest the following as areas that radiologists should focus on in order to tip the balance toward more benefits and less harms for patients undergoing imaging-based screening: interpretive variability, abnormal finding thresholds, and personalized, risk-based screening.

Indexed as

Diagnostic ErrorsDiagnostic ImagingEarly Detection of CancerHumansIncidental FindingsNeoplasmsFalse-positivesImaging-based screeningIncidental findingsOverdiagnosisScreening harms

Identifiers

PMID26112898
PMCPMC4676956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.