ArticleScientific reports2015
Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Organic Electronic Platform for Real-Time Phenotypic Screening of Extracellular-Vesicle-Driven Breast Cancer Metastasis.Advanced healthcare materials · 2023Article
- Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro-Organ Signals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The effect of side chain engineering on conjugated polymers in organic electrochemical transistors for bioelectronic applications.Journal of materials chemistry. C · 2022Review
- High Aspect Ratio and Light-Sensitive Micropillars Based on a Semiconducting Polymer Optically Regulate Neuronal Growth.ACS applied materials & interfaces · 2021Article
- A Multiparameter Pressure-Temperature-Humidity Sensor Based on Mixed Ionic-Electronic Cellulose Aerogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Biological Applications of Organic Electrochemical Transistors: Electrochemical Biosensors and Electrophysiology Recording.Frontiers in chemistry · 2019Review
- Transistor in a tube: A route to three-dimensional bioelectronics.Science advances · 2018Article
- An Organic Mixed Ion-Electron Conductor for Power Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Impedance sensing of biological systems allows for monitoring of cell and tissue properties, including cell-substrate attachment, layer confluence, and the "tightness" of an epithelial tissue. These properties are critical for electrical detection of tissue health and viability in applications such as toxicological screening. Organic transistors based on conducting polymers offer a promising route to efficiently transduce ionic currents to attain high quality impedance spectra, but collection of complete impedance spectra can be time consuming (minutes). By applying uniform white noise at the gate of an organic electrochemical transistor (OECT), and measuring the resulting current noise, we are able to dynamically monitor the impedance and thus integrity of cultured epithelial monolayers. We show that noise sourcing can be used to track rapid monolayer disruption due to compounds which interfere with dynamic polymerization events crucial for maintaining cytoskeletal integrity, and to resolve sub-second alterations to the monolayer integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.