Evidence map›Paper›PMID 26112057›Full record

ArticleAcademic radiology2015

Effect of menstrual cycle phase on background parenchymal uptake at molecular breast imaging.

Carrie B Hruska, Amy Lynn Conners, Celine M Vachon, Michael K O'Connor, Lynne T Shuster, Adam C Bartley, Deborah J Rhodes

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Advances and Future Directions in Molecular Breast Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carrie B HruskaDepartment of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905. Electronic address: hruska.carrie@mayo.edu.
Amy Lynn ConnersDepartment of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Celine M VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Michael K O'ConnorDepartment of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Lynne T ShusterDepartment of Medicine, Mayo Clinic, Rochester, Minnesota.
Adam C BartleyDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Deborah J RhodesDepartment of Medicine, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1TR000135
6 · The paper itself

Abstract

RATIONALE AND

objectivesThe level of Tc-99m sestamibi uptake within normal fibroglandular tissue on molecular breast imaging (MBI), termed background parenchymal uptake (BPU), has been anecdotally observed to fluctuate with menstrual cycle. Our objective was to assess the impact of menstrual cycle phase on BPU appearance. MATERIALS AND

methodsPremenopausal volunteers who reported regular menstrual cycles and no exogenous hormone use were recruited to undergo serial MBI examinations during the follicular and luteal phase. A study radiologist, blinded to cycle phase, categorized BPU as photopenic, minimal mild, moderate, or marked. Change in BPU with cycle phase was determined, as well as correlations of BPU with mammographic density and hormone levels.

resultsIn 42 analyzable participants, high BPU (moderate or marked) was observed more often in luteal phase compared to follicular (P = .016). BPU did not change with phase in 30 of 42 participants (71%) and increased in the luteal phase compared to follicular in 12 (29%). High BPU was more frequent in dense breasts compared to nondense breasts at both the luteal (58% [15 of 26] vs. 13% [2 of 16], P = .004) and follicular phases (35% [9 of 26] vs. 6% [1 of 16], P = .061). Spearman correlation coefficients did not show any correlation of BPU with hormone levels measured at either cycle phase and suggested a weak correlation between change in BPU and changes in estrone and estradiol between phases.

conclusionsWe observed variable effects of menstrual cycle on BPU among our cohort of premenopausal women; however, when high BPU was observed, it was most frequently seen during the luteal phase compared to follicular phase and in women with dense breasts compared to nondense breasts.

Indexed as

RadiopharmaceuticalsTechnetium Tc 99m SestamibiAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedEstradiolEstroneFollicle Stimulating HormoneProgesteroneRadiopharmaceuticalsSex Hormone-Binding GlobulinTechnetium Tc 99m SestamibiTestosteronebackground parenchymal uptakehormonesmenstrual cycleMolecular breast imaging

Identifiers

PMID26112057
PMCPMC4532620
OpenAlexW1868138040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.