Evidence map›Paper›PMID 26112012›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes.

Jenny C Link, Xuqi Chen, Christopher Prien, Mark S Borja, Bradley Hammerson, Michael N Oda, Arthur P Arnold, Karen Reue

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Exploring sex bias in cardiometabolic diseases.Lipids in health and disease · 2026
    Review
  5. Article
  6. De Novo Serum Biochemistry and Electrophoretic Reference Intervals for Jamaican Fruit Bats (Artibeus jamaicensis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Editorial: Sex differences and cardiovascular therapeutics.Frontiers in cardiovascular medicine · 2024
    Article
  18. Article
  19. The impact of chromosomal sex on cardiometabolic health and disease.Trends in endocrinology and metabolism: TEM · 2023
    Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jenny C LinkFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Xuqi ChenFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Christopher PrienFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Mark S BorjaFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Bradley HammersonFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Michael N OdaFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Arthur P ArnoldFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.).
Karen ReueFrom the Molecular Biology Institute (J.C.L., K.R.), Department of Integrative Biology and Physiology (X.C., A.P.A.), Laboratory of Neuroendocrinology of the Brain Research Institute (X.C., A.P.A.), Department of Human Genetics, David Geffen School of Medicine (C.P., K.R.), and Department of Medicine, David Geffen School of Medicine (K.R.), University of California, Los Angeles; and Children's Hospital Oakland Research Institute, California (M.S.B., B.H., M.N.O.). reuek@ucla.edu.
University of California System · US

Funding

The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Sex differences in obesity and metabolic diseaseR01DK083561 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, CHEN, XUQI · 2010 to 2014
$1.6M
NHLBI NIH HHS P01 HL090553NIDDK NIH HHS R01 DK083561NIDDK NIH HHS R01 DK83561NIDDK NIH HHS U24 DK059637NIGMS NIH HHS GM007185NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

objectiveThe molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels. APPROACH AND

resultsWe assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the four core genotypes mouse model (XX females, XX males, XY females, and XY males). In gonadally intact mice fed a chow diet, lipid levels were influenced by both male-female gonadal sex and XX-XY chromosome complement. Gonadectomy of adult mice revealed that the male-female differences are dependent on acute effects of gonadal hormones. In both intact and gonadectomized animals, XX mice had higher HDL cholesterol (HDL-C) levels than XY mice, regardless of male-female sex. Feeding a cholesterol-enriched diet produced distinct patterns of sex differences in lipid levels compared with a chow diet, revealing the interaction of gonadal and chromosomal sex with diet. Notably, under all dietary and gonadal conditions, HDL-C levels were higher in mice with 2 X chromosomes compared with mice with an X and Y chromosome. By generating mice with XX, XY, and XXY chromosome complements, we determined that the presence of 2 X chromosomes, and not the absence of the Y chromosome, influences HDL-C concentration.

conclusionsWe demonstrate that having 2 X chromosomes versus an X and Y chromosome complement drives sex differences in HDL-C. It is conceivable that increased expression of genes escaping X-inactivation in XX mice regulates downstream processes to establish sexual dimorphism in plasma lipid levels.

Indexed as

X ChromosomeY ChromosomeAnimalsBiomarkersCholesterol, HDLFemaleGene DosageGenotypeGonadal Steroid HormonesHypercholesterolemiaMaleMice, Inbred C57BLOrchiectomyOvariectomyOvaryPhenotypeBiomarkersCholesterol, HDLGonadal Steroid HormonesdietfemaleHDL cholesterolmalemice

Identifiers

PMID26112012
PMCPMC4668127
OpenAlexW2121550703

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.