Evidence map›Paper›PMID 26112011›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia.

Lu Xu, Xiaoyuan Dai Perrard, Jerry L Perrard, Donglin Yang, Xinhua Xiao, Ba-Bie Teng, Scott I Simon, Christie M Ballantyne, Huaizhu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 84 citations in OpenAlex.

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  15. CD93 in macrophages: A novel target for atherosclerotic plaque imaging?Journal of cellular and molecular medicine · 2022
    Article
  16. Identification ofThe Journal of international medical research · 2022
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  17. Article
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  19. HDL and Lipid Metabolism.Advances in experimental medicine and biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lu XuFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Xiaoyuan Dai PerrardFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Jerry L PerrardFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Donglin YangFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Xinhua XiaoFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Ba-Bie TengFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Scott I SimonFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Christie M BallantyneFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.).
Huaizhu WuFrom the Department of Medicine (L.X., X.D.P., J.L.P., D.Y., C.M.B., H.W.) and Department of Pediatrics (C.M.B., H.W.), Baylor College of Medicine, Houston, TX; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, TX (C.M.B.); Research Center for Human Genetics, Institute of Molecular Medicine, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston (B.-B.T.); Department of Biomedical Engineering, University of California, Davis (S.I.S.); and Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.X., X.X.). hwu@bcm.edu.
University of California, Davis · USBaylor College of Medicine · USCenter for Human Genetics · USThe University of Texas Health Science Center at Houston · US

Funding

Monocyte Activation and the Role of CD11c in obesity-linked metabolic syndromeR01HL098839 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WU, HUAIZHU · 2010 to 2019
$3.2M
Vascular Mimetics to Study Inflammation and AtherosclerosisR01HL082689 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PASSERINI, ANTHONY G., SIMON, SCOTT IRWIN · 2008 to 2016
$3.2M
T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced ObesityR01DK078847 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL · 2009 to 2013
$1.7M
NHLBI NIH HHS R01 HL082689NHLBI NIH HHS R01 HL098839NIDDK NIH HHS R01 DK078847
6 · The paper itself

Abstract

objectiveTo examine infiltration of blood foamy monocytes, containing intracellular lipid droplets, into early atherosclerotic lesions and its contribution to development of nascent atherosclerosis. APPROACH AND

resultsIn apoE(-/-) mice fed Western high-fat diet (WD), >10% of circulating monocytes became foamy monocytes at 3 days on WD and >20% of monocytes at 1 week. Foamy monocytes also formed early in blood of Ldlr(-/-)Apobec1(-/-) (LDb) mice on WD. Based on CD11c and CD36, mouse monocytes were categorized as CD11c(-)CD36(-), CD11c(-)CD36(+), and CD11c(+)CD36(+). The majority of foamy monocytes were CD11c(+)CD36(+), whereas most nonfoamy monocytes were CD11c(-)CD36(-) or CD11c(-)CD36(+) in apoE(-/-) mice on WD. In wild-type mice, CD11c(+)CD36(+) and CD11c(-)CD36(+), but few CD11c(-)CD36(-), monocytes took up cholesteryl ester-rich very low-density lipoproteins (CE-VLDLs) isolated from apoE(-/-) mice on WD, and CE-VLDL uptake accelerated CD11c(-)CD36(+) to CD11c(+)CD36(+) monocyte differentiation. Ablation of CD36 decreased monocyte uptake of CE-VLDLs. Intravenous injection of DiI-CE-VLDLs in apoE(-/-) mice on WD specifically labeled CD11c(+)CD36(+) foamy monocytes, which infiltrated into nascent atherosclerotic lesions and became CD11c(+) cells that were selectively localized in atherosclerotic lesions. CD11c deficiency reduced foamy monocyte infiltration into atherosclerotic lesions. Specific and consistent depletion of foamy monocytes (for 3 weeks) by daily intravenous injections of low-dose clodrosome reduced development of nascent atherosclerosis.

conclusionsFoamy monocytes, which form early in blood of mice with hypercholesterolemia, infiltrate into early atherosclerotic lesions in a CD11c-dependent manner and play crucial roles in nascent atherosclerosis development.

Indexed as

AnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCD11c AntigenCD36 AntigensCell LineCholesterol, DietaryCholesterol, VLDLDiet, High-FatDisease Models, AnimalHumansHypercholesterolemiaMaleMice, Inbred C57BLApolipoproteins ECD11c AntigenCD36 AntigensCholesterol, DietaryCholesterol, VLDLReceptors, LDLTlr4 protein, mouseToll-Like Receptor 4atherosclerosisdiet, high-fatinflammationlipoproteinsmonocytes

Identifiers

PMID26112011
PMCPMC4514542
OpenAlexW2153111316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.