Evidence map›Paper›PMID 26111939›Full record

Trial reportPharmacotherapy2015

A Cluster-Randomized Trial of a Centralized Clinical Pharmacy Cardiovascular Risk Service to Improve Guideline Adherence.

Barry L Carter, Christopher S Coffey, Elizabeth A Chrischilles, Gail Ardery, Dixie Ecklund, Brian Gryzlak, Mark W Vander Weg, Paul A James, Alan J Christensen, Christopher P Parker and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Pharmacotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02215408 (MEDication Focused Outpatient Care for Underutilization of Secondary Prevention), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02215408 nacompletednot on this map

MEDication Focused Outpatient Care for Underutilization of Secondary Prevention

TypeinterventionalSponsorKorey KenneltyRan2015 to 2018Enrolled402ConditionsDiabetes, Hyperlipidemia, Hypertension, Cardiovascular DiseaseArmsCVRS Intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Risk scoring for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Barry L CarterDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Christopher S CoffeyDepartment of Biostatistics, College of Public Health, Iowa City, Iowa.
Elizabeth A ChrischillesDepartment of Epidemiology, College of Public Health, Iowa City, Iowa.
Gail ArderyDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Dixie EcklundDepartment of Biostatistics, College of Public Health, Iowa City, Iowa.
Brian GryzlakDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Mark W Vander WegIowa City Veterans Administration, Iowa City, Iowa.
Paul A JamesDepartment of Family Medicine, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa.
Alan J ChristensenDepartment of Internal Medicine, Carver College of Medicine, Iowa City, Iowa.
Christopher P ParkerDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Tyler GumsDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Rachel J FinkelsteinDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Liz UribeDepartment of Biostatistics, College of Public Health, Iowa City, Iowa.
Linnea A PolgreenDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa.
MEDication Focused Outpatient Care for Underutilization of Secondary Prevention Trial Investigators

Funding

MEDication Focused Outpatient Care for Underutilization of Secondary PreventionR18HL116259 · NHLBI · UNIVERSITY OF IOWA · PI COFFEY, CHRISTOPHER S., KENNELTY, KOREY A · 2014 to 2018
$8.8M
NHLBI NIH HHS R18 HL116259NHLBI NIH HHS R18HL116259
6 · The paper itself

Abstract

backgroundNumerous studies have demonstrated the value of including pharmacists in team-based care to improve adherence to cardiovascular (CV) guidelines, medication adherence, and risk factor control. However, there is limited information on whether these models can be successfully implemented more widely in diverse settings and populations. The purpose of this study is to evaluate whether a centralized, web-based cardiovascular risk service (CVRS) managed by clinical pharmacists will improve guideline adherence in multiple primary care medical offices with diverse geographic and patient characteristics.

methodsThis study is a prospective trial in 20 primary care offices stratified by the percent of under-represented minorities and then randomized to either the CVRS intervention or usual care. The intervention will last for 12 months and all subjects will have research visits at baseline and 12 months. The primary outcome is the difference in guideline adherence between groups. Data will also be abstracted from the medical record at 24 months to determine if the intervention effect is sustained after it is discontinued.

conclusionsPatient enrollment will continue through 2016, with results expected in 2019. This study will provide information on whether a distant, centralized CVRS can be implemented in large numbers of medical offices, if it is effective in diverse populations, and if there is a long-term sustained effect.

Indexed as

Ambulatory CareGuideline AdherencePatient CompliancePharmaceutical ServicesCardiovascular DiseasesHumansProspective StudiesSecondary Preventioncardiovascular diseaseclinical trialdiabetesguideline adherencepharmacist management

Identifiers

PMID26111939
PMCPMC4686257

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.