ArticleBMC evolutionary biology2015
Avian influenza virus exhibits distinct evolutionary dynamics in wild birds and poultry.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 37 citations in OpenAlex.
- Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China.Virologica Sinica · 2025Article
- Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus.Science advances · 2025Article
- Article
- Evolutionary Dynamics of Avian Influenza Viruses Isolated from Wild Birds in Moscow.International journal of molecular sciences · 2023Article
- South American H4N2 influenza A virus improved replication in chicken trachea after low number of passages.Frontiers in veterinary science · 2023Article
- Phylodynamics of Highly Pathogenic Avian Influenza A(H5N1) Virus Circulating in Indonesian Poultry.Viruses · 2022Article
- Phylodynamic analysis of the highly pathogenic avian influenza H5N8 epidemic in France, 2016-2017.Transboundary and emerging diseases · 2022Article
- Article
- The Ecology and Evolution of Influenza Viruses.Cold Spring Harbor perspectives in medicine · 2020Review
- Article
- Animal Disease Surveillance in the 21st Century: Applications and Robustness of Phylodynamic Methods in Recent U.S. Human-Like H3 Swine Influenza Outbreaks.Frontiers in veterinary science · 2020Article
- Global patterns of avian influenza A (H7): virus evolution and zoonotic threats.FEMS microbiology reviews · 2019Review
- Genetic relationship between poultry and wild bird viruses during the highly pathogenic avian influenza H5N6 epidemic in the Netherlands, 2017-2018.Transboundary and emerging diseases · 2019Article
- Review
- Article
- Geographical and Historical Patterns in the Emergences of Novel Highly Pathogenic Avian Influenza (HPAI) H5 and H7 Viruses in Poultry.Frontiers in veterinary science · 2018Article
- The impact of migratory flyways on the spread of avian influenza virus in North America.BMC evolutionary biology · 2017Article
- Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts.PLoS pathogens · 2016Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWild birds are the major reservoir hosts for influenza A viruses, occasionally transmitting to other species such as domesticated poultry. Despite an abundance of genomic data from avian influenza virus (AIV), little is known about whether AIV evolves differently in wild birds and poultry, although this is critical to revealing the dynamics and time-scale of viral evolution. In particular, because environmental (water-borne) transmission is more common in wild birds, which may reduce the number of replications per unit time, it is possible that evolutionary rates are systematically lower in wild birds than in poultry.
resultsWe estimated rates of nucleotide substitution in two AIV subtypes that are strongly associated with infections in wild birds - H4 and H6 - and compared these to rates in the H5N1 subtype that has circulated in poultry for almost two decades. Our analyses of three internal genes confirm that H4 and H6 viruses are evolving significantly more slowly than H5N1 viruses, suggesting that evolutionary rates of AIV are reduced in wild birds. This result was verified by the analysis of a poultry-associated H6 lineage that exhibited a markedly higher substitution rate than those H6 viruses circulating in wild birds. Interestingly, we also observed a significant difference in evolutionary rate between H4 and H6, despite frequent reassortment rate among them.
conclusionsAIV experiences markedly different evolutionary dynamics between wild birds and poultry. These results suggest that rate heterogeneity among viral subtypes and ecological groupings should be taken into account when estimating evolutionary rates and divergence times.
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