Evidence map›Paper›PMID 26111777›Full record

ArticleAging cell2015

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Assaf Ben-Meir, Eliezer Burstein, Aluet Borrego-Alvarez, Jasmine Chong, Ellen Wong, Tetyana Yavorska, Taline Naranian, Maggie Chi, Ying Wang, Yaakov Bentov and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515134 (Follicular Fluid Coenzyme Q10 Level in Women Undergoing Intracytoplasmic Sperm Injection), which is not on this map. Cited by 239 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04515134 unknown statusnot on this mapstarted 2021, after this paper: background citation

Follicular Fluid Coenzyme Q10 Level in Women Undergoing Intracytoplasmic Sperm Injection

TypeobservationalSponsorSouth Valley UniversityRan2021 to 2022Enrolled100ConditionsPregnancy OutcomeArmsassessment of follicular level of coenzyme Q10 in the ovaries in females undergoing ICSI
3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 3 syntheses or guidelines pooled it, 453 citations in OpenAlex.

  1. Pooled it
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  3. The efficacy of coenzyme QJournal of cellular and molecular medicine · 2022
    Pooled it
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  20. hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Assaf Ben-MeirLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Eliezer BursteinLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Aluet Borrego-AlvarezLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Jasmine ChongLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Ellen WongLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Tetyana YavorskaLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Taline NaranianLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Maggie ChiDepartment of Obstetrics and Gynecology, Washington University in St. Louis, 660 S. Euclid Avenue, St. Louis, MO, 63110, USA.
Ying WangDepartment of Biology, McGill University, 3649 Promenade Sir William Osler, Montreal, QC, H3G 0B1, Canada.
Yaakov BentovTCART Fertility Partners, 150 Bloor W, Toronto, ON, M5S 2X9, Canada.
Jennifer AlexisLifeQuest Centre for Reproductive Medicine, 655 Bay St, Toronto, ON, M5G 2K4, Canada.
James MerianoLifeQuest Centre for Reproductive Medicine, 655 Bay St, Toronto, ON, M5G 2K4, Canada.
Hoon-Ki SungLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
David L GasserDepartment of Genetics, University of Pennsylvania, 575 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Kelle H MoleyDepartment of Obstetrics and Gynecology, Washington University in St. Louis, 660 S. Euclid Avenue, St. Louis, MO, 63110, USA.
Siegfried HekimiDepartment of Biology, McGill University, 3649 Promenade Sir William Osler, Montreal, QC, H3G 0B1, Canada.
Robert F CasperLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Andrea JurisicovaLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, M5T 3H7, Canada.
Mount Sinai Hospital · CACReATe Fertility Centre · CACanada Research Chairs · CALunenfeld-Tanenbaum Research Institute · CAMcGill University · CAPacific Centre for Reproductive Medicine · CAWashington University in St. Louis · USUniversity of Pennsylvania · US

Funding

Canadian Institutes of Health Research 112220Canadian Institutes of Health Research 123518Canadian Institutes of Health Research 14058Canadian Institutes of Health Research 84328
6 · The paper itself

Abstract

Female reproductive capacity declines dramatically in the fourth decade of life as a result of an age-related decrease in oocyte quality and quantity. The primary causes of reproductive aging and the molecular factors responsible for decreased oocyte quality remain elusive. Here, we show that aging of the female germ line is accompanied by mitochondrial dysfunction associated with decreased oxidative phosphorylation and reduced Adenosine tri-phosphate (ATP) level. Diminished expression of the enzymes responsible for CoQ production, Pdss2 and Coq6, was observed in oocytes of older females in both mouse and human. The age-related decline in oocyte quality and quantity could be reversed by the administration of CoQ10. Oocyte-specific disruption of Pdss2 recapitulated many of the mitochondrial and reproductive phenotypes observed in the old females including reduced ATP production and increased meiotic spindle abnormalities, resulting in infertility. Ovarian reserve in the oocyte-specific Pdss2-deficient animals was diminished, leading to premature ovarian failure which could be prevented by maternal dietary administration of CoQ10. We conclude that impaired mitochondrial performance created by suboptimal CoQ10 availability can drive age-associated oocyte deficits causing infertility.

Indexed as

AgingAnimalsFemaleFertilityMiceMice, TransgenicMitochondriaOocytesReproductionUbiquinonecoenzyme Q10Ubiquinoneanti-agingfecundityindividualMitochondriamolecular biology of agingmouse models

Identifiers

PMID26111777
PMCPMC4568976
OpenAlexW1949822692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.